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©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Hepatol. Mar 27, 2020; 12(3): 108-115
Published online Mar 27, 2020. doi: 10.4254/wjh.v12.i3.108
Published online Mar 27, 2020. doi: 10.4254/wjh.v12.i3.108
Successful liver transplantation for acute sickle cell intrahepatic cholestasis: A case report and review of the literature
Motasem Alkhayyat, Mohammad Zmaili, Vedha Sanghi, Department of Internal Medicine, Cleveland Clinic, Cleveland, OH 44195, United States
Mohannad Abou Saleh, Tavankit Singh, Carol Rouphael, C Roberto Simons-Linares, Carlos Romero-Marrero, William D Carey, Christina C Lindenmeyer, Digestive Disease & Surgery Institute, Department of Gastroenterology, Hepatology & Nutrition, Cleveland Clinic, Cleveland, OH 44195, United States
Author contributions: Alkhayyat M, Saleh MA, Zmaili M and Sanghi V reviewed the literature and contributed to manuscript drafting; Singh T, Rouphael C, Simons-Linares CR, Romero-Marrero C, Carey WD and Lindenmeyer CC reviewed and contributed to the manuscript; all authors issued final approval for the version to be submitted.
Informed consent statement: Informed written consent was obtained for publication of this report and any accompanying images.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Christina C Lindenmeyer, MD, Staff Physician, Department of Gastroenterology, Hepatology & Nutrition, Cleveland Clinic, 9500 Euclid Ave Mail Code A51, Cleveland, OH 44195, United States. lindenc@ccf.org
Received: September 13, 2019
Peer-review started: September 13, 2019
First decision: September 26, 2019
Revised: December 28, 2019
Accepted: February 17, 2020
Article in press: February 17, 2020
Published online: March 27, 2020
Peer-review started: September 13, 2019
First decision: September 26, 2019
Revised: December 28, 2019
Accepted: February 17, 2020
Article in press: February 17, 2020
Published online: March 27, 2020
Core Tip
Core tip: Acute sickle cell intrahepatic cholestasis is a rare and life-threatening form of sickle cell hepatopathy, with a mortality rate approaching 40%. Patients typically present with fever, abdominal pain and jaundice. Rarely, it may progress to an acute liver failure phenotype, commonly associated with multi-system organ failure. Diagnosis is made after excluding other causes of acute liver injury. Treatment options include exchange blood transfusion and liver transplantation.