Obeticholic acid attenuates human immunodeficiency virus/alcohol metabolism-induced pro-fibrotic activation in liver cells
Moses New-Aaron, Murali Ganesan, Raghubendra Singh Dagur, Kusum K Kharbanda, Larisa Y Poluektova, Natalia A Osna
Moses New-Aaron, Department of Environmental, Agriculture and Occupational Health, College of Public Health, University of Nebraska Medical Center, Omaha, NE 68105, United States
Moses New-Aaron, Murali Ganesan, Raghubendra Singh Dagur, Kusum K Kharbanda, Natalia A Osna, Research Service, Veterans Affairs Nebraska-Western Iowa Health Care System, Omaha, NE 68105, United States
Murali Ganesan, Raghubendra Singh Dagur, Kusum K Kharbanda, Natalia A Osna, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE 68105, United States
Larisa Y Poluektova, Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198, United States
Author contributions: New-Aaron M and Dagur RS performed the experiments, acquired, analyzed and interpreted the data; New-Aaron M and Osna NA drafted the manuscript; Ganesan M, Kharbanda KK and Poluektova LY contributed to critical revision, editing of the manuscript; Osna NA contributed to conception, design and funding of the study; all authors approved the final version of the article.
Supported by The National Institutes of Health, No. R01AA027189-01A1.
Institutional review board statement: The study was reviewed and approved by the Subcommittee for Research and Development Review Board at Veterans Affairs Medical Center, Omaha, United States.
Conflict-of-interest statement: Moses New-Aaron, Murali Ganesan, Raghubendra Singh Dagur, Kusum K. Kharbanda, Larisa Y Poluektova , Natalia A. Osna. All authors have nothing to disclose.
Data sharing statement: No additional data are available.
ARRIVE guidelines statement: The authors have read the ARRIVE guidelines, and the manuscript was prepared and revised according to the ARRIVE guidelines.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
http://creativecommons.org/Licenses/by-nc/4.0/ Corresponding author: Natalia A Osna, MD, PhD, Associate Professor, Research Service, Veterans Affairs Nebraska-Western Iowa Health Care System, No. 4101 Woolworth Ave, Omaha, NE 68105, United States. nosna@unmc.edu
Received: July 16, 2020
Peer-review started: July 16, 2020
First decision: September 14, 2020
Revised: September 16, 2020
Accepted: October 5, 2020
Article in press: October 5, 2020
Published online: November 27, 2020
