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©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Hepatol. Jul 27, 2019; 11(7): 596-606
Published online Jul 27, 2019. doi: 10.4254/wjh.v11.i7.596
Published online Jul 27, 2019. doi: 10.4254/wjh.v11.i7.596
Spontaneous fungal peritonitis: Micro-organisms, management and mortality in liver cirrhosis-A systematic review
Tooba Tariq, Mehdi Farishta, Eric Martin Sieloff, Department of Internal Medicine, Western Michigan University, Kalamazoo, MI 49008, United States
Furqan B Irfan, College of Osteopathic Medicine, Michigan State University, WEast Lansing, MI 48824, United States
Brian Dykstra, Department of Pulmonary and Critical Care Medicine, Western Michigan University, Kalamazoo, MI 49008, United States
Archita P Desai, Division of Gastroenterology and Hepatology, Indiana University School of Medicine, Indianapolis, IN 46202, United States
Author contributions: Tariq T, Irfan FB, Farishta M, Dykstra B and Desai AP contributed equally to the work; Tariq T and Irfan FB conceptualized and designed the study together; Irfan FB and Farishta M screened the studies for inclusion and carried out the data collection and data extraction; Dykstra B, Sieloff M and Desai AP carried out the analysis and critically analyzed the study; Tariq T, Irfan FB and Desai AP drafted the initial manuscript; all authors reviewed and approved the final manuscript as submitted.
Conflict-of-interest statement: None declared in agreement with all co-authors.
Open-Access: This is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Tooba Tariq, MD, Instructor, Department of Internal Medicine, Western Michigan University, 1000 Oakland Drive, Kalamazoo, MI 49008, United States. toobatariq31@gmail.com
Telephone: +1-217-9045659 Fax: +1-269-3376222
Received: May 28, 2019
Peer-review started: May 29, 2019
First decision: June 10, 2019
Revised: June 15, 2019
Accepted: July 4, 2019
Article in press: July 5, 2019
Published online: July 27, 2019
Peer-review started: May 29, 2019
First decision: June 10, 2019
Revised: June 15, 2019
Accepted: July 4, 2019
Article in press: July 5, 2019
Published online: July 27, 2019
Core Tip
Core tip: Spontaneous fungal peritonitis (SFP) in patients with cirrhosis is associated with high in-hospital mortality rate of 33.3% to 100% and 1-mo mortality rate of 50% to 73.3%. In our systematic review of the literature, despite such high mortality rates, the condition is under diagnosed and antifungal therapy is underutilized; 33.3% to 81.8% SFP patients received anti-fungal therapy. High clinical suspicion, new methods of early diagnosis and empiric treatment in critically ill patients with peritonitis may improve outcomes.