Randomized Clinical Trial
Copyright ©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Hepatol. Mar 27, 2019; 11(3): 305-317
Published online Mar 27, 2019. doi: 10.4254/wjh.v11.i3.305
Preoperative immunonutrition in patients undergoing liver resection: A prospective randomized trial
Kylie Russell, Han-Guang Zhang, Lyn K Gillanders, Adam SJR Bartlett, Helena L Fisk, Philip C Calder, Peter J Swan, Lindsay D Plank
Kylie Russell, Lyn K Gillanders, Nutrition Services, Auckland City Hospital, Auckland 1023, New Zealand
Han-Guang Zhang, Adam SJR Bartlett, Peter J Swan, Lindsay D Plank, Department of Surgery, University of Auckland, Auckland 1023, New Zealand
Adam SJR Bartlett, New Zealand Liver Transplant Unit, Auckland City Hospital, Auckland 1023, New Zealand
Helena L Fisk, Philip C Calder, Human Development and Health, Faculty of Medicine, University of Southampton, Southampton SO171BJ, United Kingdom
Philip C Calder, NIHR Southampton Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust and University of Southampton, Southampton SO166YD, United Kingdom
Author contributions: Russell K, Zhang HG, Gillanders LK, Bartlett AJSR and Plank LD designed the study; Russell K, Zhang HG, Fisk HL, and Plank LD acquired the data; Russell K, Zhang H-G and Plank LD analysed and interpreted the data; Gillanders LK, Bartlett AJSR, Calder PC and Swan PJ contributed to interpretation of the results; Russell K and Plank LD wrote the manuscript; Gillanders LK, Bartlett AJSR, Fisk HL, Calder PC and Swan PJ provided critical revisions of the manuscript; all authors read and approved the final version of the manuscript.
Supported by: Australasian Society for Parenteral and Enteral Nutrition Research Grant and A+ Trust Small Project Grant, No. 5576.
Institutional review board statement: The study was reviewed and approved by the New Zealand Health and Disability Ethics Northern A Committee (NTX/12/06/056).
Clinical trial registration statement: This study is registered with the Australian and New Zealand Clinical Trials Registry (ACTRN12612001151820).
Informed consent statement: All study participants provided written informed consent prior to study enrolment.
Conflict-of-interest statement: None of the authors has any conflicts of interest related to this study.
Data sharing statement: No additional data are available.
CONSORT 2010 statement: The authors have read the CONSORT 2010 Statement and the manuscript was prepared according to the CONSORT 2010 Statement.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Lindsay D Plank, DPhil, Associate Professor, Department of Surgery, University of Auckland, 2 Park Road, Auckland 1023, New Zealand. l.plank@auckland.ac.nz
Telephone: +64-9-9236949 Fax: +64-9-3779656
Received: October 25, 2018
Peer-review started: October 26, 2018
First decision: December 19, 2018
Revised: February 22, 2019
Accepted: March 16, 2019
Article in press: March 16, 2019
Published online: March 27, 2019
Core Tip

Core tip: Whether immunonutritional supplementation provided preoperatively to patients undergoing liver resection can reduce postoperative inflammation and improve clinical outcome compared to standard care remains unclear. We conducted a prospective randomized trial to clarify this. We found no significant suppression of postoperative inflammation or reduction in infectious complications or length of hospital stay post-surgery through providing preoperative immunonutrition.