Published online Feb 27, 2018. doi: 10.4254/wjh.v10.i2.347
Peer-review started: November 1, 2017
First decision: December 1, 2017
Revised: December 20, 2017
Accepted: January 23, 2018
Article in press: January 24, 2018
Published online: February 27, 2018
Core tip: Primary hepatic peripheral T-cell lymphoma (H-PTCL) is one of the rarest forms of non-Hodgkin lymphoma. We report a patient who presented with worsening jaundice, abdominal pain, and vomiting. Laboratory values were significant for elevated total bilirubin, alkaline phosphatase, and liver aminotransferases. Liver biopsy followed by histopathology confirmed the diagnosis of H-PTCL. Furthermore, bone marrow biopsy was negative for malignancy, further supporting hepatic origin. Our patient’s medical history reported a prior Epstein-Barr viral infection, a risk factor for H-PTCL. In the setting of risk factors, H-PTCL should be born in mind when a patient presents with symptoms of malignancy, and an enlarged and infiltrating liver.