Copyright ©The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Hepatol. Feb 27, 2018; 10(2): 337-346
Published online Feb 27, 2018. doi: 10.4254/wjh.v10.i2.337
Outcomes of kidney transplantation in patients with hepatitis B virus infection: A systematic review and meta-analysis
Charat Thongprayoon, Wisit Kaewput, Konika Sharma, Karn Wijarnpreecha, Napat Leeaphorn, Patompong Ungprasert, Ankit Sakhuja, Franco H Cabeza Rivera, Wisit Cheungpasitporn
Charat Thongprayoon, Konika Sharma, Karn wijarnpreecha, Department of Internal Medicine, Bassett Medical Center, Cooperstown, NY 13326, United States
Wisit Kaewput, Department of Military and Community Medicine, Phramongkutklao College of Medicine, Bangkok 10400, Thailand
Napat Leeaphorn, Division of Nephrology, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, United States
Patompong Ungprasert, Clinical Epidemiology Unit, Department of Research and development, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand
Ankit Sakhuja, Division of Pulmonary and Critical Care Medicine, Department of Medicine, Mayo Clinic, Rochester, MN 55905, United States
Franco H Cabeza Rivera, Wisit Cheungpasitporn, Division of Nephrology, Department of Medicine, University of Mississippi Medical Center, Jackson, MS 39216, United States
Author contributions: Thongprayoon C, Kaewput W, Sharma K and Leeaphorn N collected the data; Thongprayoon C analyzed the data; Thongprayoon C, Sharma K, Wijarnpreecha K, Leeaphorn N, Ungprasert P, Sakhuja A and Cabeza Rivera FH interpreted the data; Thongprayoon C and Kaewput W drafted the article; Wijarnpreecha K, Ungprasert P, Sakhuja A and Cabeza Rivera FH revised the article; Cheungpasitporn W made the conception and design of the study, and critically revised the article; all the authors made the final approval of the manuscript.
Conflict-of-interest statement: The authors deny any conflict of interest.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Correspondence to: Wisit Cheungpasitporn, MD, Assistant Professor, Division of Nephrology, Department of Medicine, University of Mississippi Medical Center, Mississippi, 2500 N. State St., Jackson, MS 39216, United States.
Telephone: +1-518-2589978 Fax: +1-601-9845765
Received: November 28, 2017
Peer-review started: November 28, 2017
First decision: December 18, 2017
Revised: January 10, 2018
Accepted: February 5, 2018
Article in press: February 5, 2018
Published online: February 27, 2018
Core Tip

Core tip: Hepatitis B is one of the most common infectious diseases worldwide. Despite advances in medicine, chronic hepatitis B virus (HBV) infection is currently incurable. In addition, clinical outcomes of kidney transplantation in HBV infected patients are still unclear. To further assess these outcomes, we conducted this systematic review and meta-analysis to assess patient and allograft outcomes after kidney transplantation in patients with HBV Infection. We found significant associations between HBV positive status and poor outcomes including 2.5-fold increased risk of mortality and 1.5-fold increased risk of allograft loss.