Published online Feb 27, 2018. doi: 10.4254/wjh.v10.i2.172
Peer-review started: November 12, 2017
First decision: December 4, 2017
Revised: December 22, 2017
Accepted: January 22, 2018
Article in press: January 24, 2018
Published online: February 27, 2018
Core tip: Glycogenic hepatopathy (GH) is considered as a benign reversible condition. Elevation in transaminases is a common finding in patients with diabetes mellitus, and non-alcoholic fatty liver disease (NAFLD) and GH are the two primary underlying pathologies in most cases. It is essential to distinguish NAFLD from GH as this can progress to advanced liver disease. However, recent studies have identified the varying degree of fibrosis in glycogen hepatopathy as well, further emphasizing the need for future studies. We briefly reviewed the literature on mechanisms involved in the development of GH, evaluation of these patients, recent progress made on diagnostic tests and management.