Published online Nov 27, 2018. doi: 10.4254/wjh.v10.i11.790
Peer-review started: July 31, 2018
First decision: August 20, 2018
Revised: September 10, 2018
Accepted: October 9, 2018
Article in press: October 10, 2018
Published online: November 27, 2018
Core tip: There is an urgent need for an effective treatment of nonalcoholic fatty liver disease (NAFLD). Growing evidence indicates that reducing insulin resistance can result in improvement of the biochemical and histological features of patients with nonalcoholic steatohepatitis (NASH). However, no antidiabetic agent to date has been proven as both safe and effective for the treatment of patients with NASH. Recent studies have demonstrated that glucagon-like peptide-1 agonists, a novel class of antidiabetic drugs, may be effective in slowing the progression of NAFLD, highlighting their potential role in the treatment of this complex disease.