Copyright ©The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Hepatol. Jan 27, 2018; 10(1): 142-154
Published online Jan 27, 2018. doi: 10.4254/wjh.v10.i1.142
Vitamin D levels do not predict the stage of hepatic fibrosis in patients with non-alcoholic fatty liver disease: A PRISMA compliant systematic review and meta-analysis of pooled data
Behnam Saberi, Alia S Dadabhai, Julie Nanavati, Lin Wang, Russell T Shinohara, Gerard E Mullin
Behnam Saberi, Alia S Dadabhai, Gerard E Mullin, Division of Gastroenterology and Hepatology, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, United States
Behnam Saberi, Division of Liver Diseases, Icahn School of Medicine at Mount Sinai, New York, NY 10029, United States
Julie Nanavati, Welch Medical Library, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, United States
Lin Wang, Department of Epidemiology, Johns Hopkins-Bloomberg School of Public Health, Baltimore, MD 21205, United States
Russell T Shinohara, Department of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, United States
Author contributions: Saberi B, Dadabhai AS and Mullin GE contributed to the data evaluation, manuscript and figure preparation, editing and final submission; Shinohara RT and Wang L provided biostatistics methodology oversight, as well as data extractions, meta-analysis with pooled data figure preparation and manuscript preparation and editing; Nanavati J provided informatics methodology support, conducted the literature search, and reviewed and edited the manuscript.
Conflict-of-interest statement: None.
Data sharing statement: The authors of the following studies were contacted to obtain their approval to share data in order to systematically evaluate their data for our meta-analysis: Drs. Patel, Luger, Barchetta, Anty, Bril, and Targher.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Correspondence to: Gerard E Mullin, MD, Associate Professor, Department of Gastroenterology and Hepatology, The Johns Hopkins Hospital, 600 N Wolfe Street, Carnegie 464B, Baltimore, MD 21287, United States.
Telephone: +1-410-5024270 Fax: +1-410-5024478
Received: November 7, 2017
Peer-review started: November 8, 2017
First decision: December 4, 2017
Revised: December 12, 2017
Accepted: January 15, 2018
Article in press: January 15, 2018
Published online: January 27, 2018
Core Tip

Core tip: Non-alcoholic fatty liver disease (NAFLD) is a condition that can progress to cirrhosis, hepatic failure, and liver cancer. Vitamin D sufficiency is impaired in the advanced stages of liver disease and in NAFLD. However, our systematic review of the literature and meta-regression confirms that the serum 25-hydroxyvitamin D levels in patients with NAFLD are not associated with the severity of hepatic fibrosis.