Published online Dec 27, 2021. doi: 10.4254/wjh.v13.i12.2128
Peer-review started: June 29, 2021
First decision: August 18, 2021
Revised: August 24, 2021
Accepted: November 15, 2021
Article in press: November 15, 2021
Published online: December 27, 2021
Readmissions of alcoholic liver cirrhosis (ALC) are associated with poor outcomes.
There is paucity of data on the trends of 30-d readmissions of ALC in the United States despite it being a significant healthcare burden.
The primary objective of this study was to identify and assess trends of 30-d readmissions of ALC in the United States over an eight-year period.
This retrospective interrupted trend study used the National Readmissions Database to identify all 30-d readmissions of ALC. Multivariate regression analysis was used to calculate the trend for risk-adjusted odds of 30-d all-cause ALC readmissions, ALC specific readmission rate, ALC readmission proportion, mortality, mean length of stay (LOS) and mean total hospital cost (THC).
There was a trend towards increasing total 30-d readmissions of ALC, risk-adjusted 30-d all-cause ALC readmission, ALC specific readmission rate, and ALC readmission proportion. However, inpatient mortality declined from 10.5% in 2010 to 8.2% in 2018. The total days of hospital stay attributable to 30-d readmissions of ALC increased by 119.2% while the total attributable hospital costs increased by 149% by the end of 2018.
The total number of 30-d readmissions of ALC increased; however, inpatient mortality declined. There was a trend towards increasing LOS and THC for these readmissions.
Future studies are needed to investigate the treatment aspects of ALC in an inpatient setting. Additionally, the impact of early enrollment of patients into alcohol rehabilitation programs, patient education, regular outpatient follow-up and early effective alcohol use disorder treatments in the outpatient setting to prevent readmissions of ALC in is yet to be determined.