Retrospective Cohort Study
Copyright ©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Hepatol. Dec 27, 2020; 12(12): 1239-1257
Published online Dec 27, 2020. doi: 10.4254/wjh.v12.i12.1239
Comparison between hepatocellular carcinoma prognostic scores: A 10-year single-center experience and brief review of the current literature
Michele Campigotto, Mauro Giuffrè, Anna Colombo, Alessia Visintin, Alessandro Aversano, Martina Budel, Flora Masutti, Cristiana Abazia, Lory Saveria Crocé
Michele Campigotto, Mauro Giuffrè, Anna Colombo, Alessia Visintin, Alessandro Aversano, Martina Budel, Lory Saveria Crocé, Dipartimento Universitario Clinico di Scienze Mediche, Chirurgiche e Della Salute, Università degli Studi di Trieste, Trieste 34149, Italy
Flora Masutti, Cristiana Abazia, Lory Saveria Crocé, Clinica Patologie del Fegato, Azienda Sanitaria Universitaria Giuliano Isontina, Trieste 34149, Italy
Author contributions: Campigotto M, Giuffrè M and Crocé LS conceived the study and drafted the manuscript; Colombo A, Visintin A, Aversano A, Budel M, Masutti F, and Colombo A collected the data; All authors reviewed the final version of the manuscript.
Institutional review board statement: The study was conducted retrospectively, without performing any intervention on patients.
Informed consent statement: All study participants or their legal guardian provided informed written consent about personal and medical data collection prior to study enrolment.
Conflict-of-interest statement: The authors have no conflicts of interest to declare.
Data sharing statement: All data requests should be submitted to the corresponding author for consideration. Access to anonymized data may be granted following review.
STROBE statement: The authors have read the STROBE Statement—checklist of items, and the manuscript was prepared and revised according to the STROBE Statement—checklist of items.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Mauro Giuffrè, MD, MSc, Academic Fellow, Dipartimento Universitario Clinico di Scienze Mediche, Chirurgiche e Della Salute, Università degli Studi di Trieste, No. 447 Strada di Fiume, Trieste 34149, Italy. gff.mauro@gmail.com
Received: June 30, 2020
Peer-review started: June 30, 2020
First decision: August 9, 2020
Revised: August 14, 2020
Accepted: October 9, 2020
Article in press: October 9, 2020
Published online: December 27, 2020
ARTICLE HIGHLIGHTS
Research background

Hepatocellular carcinoma represents the most common primitive liver malignancy.

Research motivation

Currently there is a widespread lack of agreement on staging systems, prognostic scores and treatment allocation algorithms.

Research objectives

Define the prognostic ability of fifteen different prognostic scores.

Research methods

Retrospective study, 10-year enrollment of patients.

Research results

With the Italian Liver Cancer (ITA.LI.CA) prognostic system 28.6%, 40.7%, 22.1% and 8.6% of patients fell within stages 0-1, 2-3, 4-5 and > 5 respectively. The median survival was 57.9 mo for stages 0-1, 43 mo for stages 2-3, 21.7 mo for stages 4-5 and 10.4 mo for stage > 5. 1-, 3-, and 5-year survival rates were 95%, 65% and 20% for stages 0-1, 94.7%, 43.9% and 26.3% for stages 2-3, 71%, 25.8% and 16.1% for stages 4-5 and 50%, 16.7% and 8.3% for stage > 5.

Research conclusions

The median overall survival of the cohort of patients was 35 (17; 67) mo, and it was statistically different in relation to treatment choice, ultrasound surveillance and serum AFP.

Research perspectives

External validation to the ITA.LI.CA staging system.