Rodríguez-Leal GA, Morán S, Corona-Cedillo R, Brom-Valladares R. Portal vein thrombosis with protein C-S deficiency in a non-cirrhotic patient. World J Hepatol 2014; 6(7): 532-537 [PMID: 25068006 DOI: 10.4254/wjh.v6.i7.532]
Corresponding Author of This Article
Segundo Morán, MD, Laboratory of Gastrohepatology Research, Hospital de Pediatría, CMN Siglo XXI, Mexican Institute of Social Security, Av Cuauhtémoc 330, Colonia Doctores, Delegación Cuauhtémoc, CP 06720, México. segundomoran@hotmail.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Case Report
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Hepatol. Jul 27, 2014; 6(7): 532-537 Published online Jul 27, 2014. doi: 10.4254/wjh.v6.i7.532
Portal vein thrombosis with protein C-S deficiency in a non-cirrhotic patient
Gustavo A Rodríguez-Leal, Segundo Morán, Roberto Corona-Cedillo, Rocío Brom-Valladares
Gustavo A Rodríguez-Leal, Segundo Morán, Laboratory of Gastrohepatology Research, Hospital de Pediatría, CMN Siglo XXI, Mexican Institute of Social Security, Delegación Cuauhtémoc, CP 06720, México
Gustavo A Rodríguez-Leal, Gastroenterology Department, Médica Sur Clinic and Foundation, Ciudad de México, DF 14050, México
Roberto Corona-Cedillo, Rocío Brom-Valladares, Radiology Department, Médica Sur Clinic and Foundation, Ciudad de México, DF 14050, México
Author contributions: Rodríguez-Leal GA drafted the manuscript, provided patient details and made the suggested revisions; Morán S assisted in drafting the manuscript, reviewed the manuscript and made suggestions on revisions, and assisted with journal submission; Corona-Cedillo R and Brom-Valladares R reviewed the manuscript and made suggestions on revisions, and provided the radiologic material and comments.
Correspondence to: Segundo Morán, MD, Laboratory of Gastrohepatology Research, Hospital de Pediatría, CMN Siglo XXI, Mexican Institute of Social Security, Av Cuauhtémoc 330, Colonia Doctores, Delegación Cuauhtémoc, CP 06720, México. segundomoran@hotmail.com
Telephone: +52-55-56276900 Fax: +52-55-57610952
Received: December 4, 2013 Revised: March 11, 2014 Accepted: May 28, 2014 Published online: July 27, 2014
Abstract
There are several conditions that can lead to portal vein thrombosis (PVT), including including infection, malignancies, and coagulation disorders. Anew condition of interest is protein C and S deficiencies, associated with hypercoagulation and recurrent venous thromboembolism. We report the case of a non-cirrhotic 63-year-old male diagnosed with acute superior mesenteric vein thrombosis and PVT and combined deficiencies in proteins C and S, recanalized by short-term low molecular heparin plus oral warfarin therapy.
Core tip: Abdominal pain, diarrhea, rectal bleeding, abdominal distention, ascites, anorexia, fever, lactacidosis, sepsis, and splenomegaly are common features of acute portal vein thrombosis (PVT). Etiological factors in non-cirrhotic PVT patients are prothrombotic states and local factors, although more than one factor is often identified. Our patient, a 63-year-old man, without personal or familial history of venous thromboembolism developed portal and mesenteric vein thrombosis after an acute gastrointestinal infection by Escherichia coli. Clinicians need to be aware of this potential complication in patients with persistent abdominal pain and ascites after abdominal infections.
