Perceptions of post-transplant recidivism in liver transplantation for alcoholic liver disease

Abstract

Although alcoholic liver disease (ALD) is regarded as a common indication for liver transplantation (LT), debatable issues exist on the requirement for preceding alcoholic abstinence, appropriate indication criteria, predictive factors for alcoholic recidivism, and outcomes following living-donor LT. In most institutions, an abstinence period of six months before LT has been adopted as a mandatory selection criterion. Data indicating that pre-transplant abstinence is an associated predictive factor for alcoholic recidivism supports the reasoning behind this. However, conclusive evidence about the benefit of adopting an abstinence period is yet to be established. On the other hand, a limited number of reports available on living-donor LT experiences for ALD patients suggest that organ donations from relatives have no suppressive effect on alcoholic recidivism. Prevention of alcoholic recidivism has proved to be the most important treatment after LT based on the resultant inferior long-term outcome of patients. Further evaluations are still needed to establish strategies before and after LT for ALD.

Keywords: Abstinence, Alcoholic liver disease, Liver transplantation, Six-month rule

Core tip: Prevention of alcoholic recidivism has proved to be the most important treatment after liver transplantation based on inferior long-term outcome of patients. Further evaluations, however, are still needed to establish strategies before and after liver transplantation with alcoholic liver diseases.