Published online Apr 27, 2013. doi: 10.4254/wjh.v5.i4.214
Revised: January 7, 2013
Accepted: February 28, 2013
Published online: April 27, 2013
AIM: To determine the prevalence of hepatitis B surface antigen (HBsAg) seropositivity among adult Filipinos.
METHODS: Testing for HBsAg was performed on serum samples from persons aged ≥ 20 years old who participated in the National Nutrition and Health Survey (NNHeS) conducted in 2003. Information on age, sex, marital status, educational attainment, employment status, and income were collected. For this study, marital status was classified as never married or otherwise (i.e., married, divorced, separated, widowed); educational attainment was classified as high school graduate or below or at least some tertiary education; and employment status was classified as currently employed or currently unemployed. Annual income was divided into 4 quartiles in Philippine pesos (PhP): Q1, ≤ PhP 53064; Q2, PhP 53065-92192; Q3, PhP 92193-173387; and Q4, ≥ PhP 173388. Prevalence estimates were weighted so that they represented the general population. Social and demographic factors were correlated with HBsAg seropositivity. Multivariate analysis was used to determine independent predictors of HBsAg seropositivity.
RESULTS: A total of 2150 randomly selected adults, 20 years and over, out of the 4753 adult participants of NNHeS were tested for HBsAg. The HBsAg seroprevalence was 16.7% (95%CI: 14.3%-19.1%), which corresponded to an estimated 7278968 persons infected with hepatitis B. There was no significant difference between males and females (17.5% vs 16.0%; P = 0.555). This corresponded to an estimated 3721775 men and 3557193 women infected with hepatitis B. The HBsAg seroprevalence peaked at age 20-39 years old, with declining prevalence in the older age groups. The only independent predictor of HBsAg seropositivity was the annual income, with persons in the highest income quartile being less likely to be HBsAg positive (age-adjusted OR = 0.51; 95%CI: 0.30-0.86) compared to subjects in the lowest income quartile. Sex, marital status, educational attainment, and employment status were not found to be independent predictors of HBsAg seropositivity.
CONCLUSION: The high HBsAg seroprevalence among adults in the Philippines classifies the country as hyperendemic for HBV infection and appears unchanged over the last few decades.
Core tip: Chronic hepatitis B has a significant public health impact in the Philippines because it is a common cause of end stage liver disease and is the leading cause of hepatocellular carcinoma, the latter being the fourth leading cancer and the second leading cause of cancer death in the country. However, an accurate estimate of the national prevalence of hepatitis B infection in the Philippines is lacking. To determine the national prevalence of hepatitis B infection in the Philippines, testing for hepatitis B surface antigen was undertaken on serum samples collected from subjects included in the National Nutrition and Health Survey.