Case Report
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World J Hepatol. Nov 27, 2012; 4(11): 314-318
Published online Nov 27, 2012. doi: 10.4254/wjh.v4.i11.314
Co-existence of hepatocellular adenoma and focal nodular hyperplasia in a young female
Dimitrios Dimitroulis, Panagiotis Lainas, Petros Charalampoudis, Theodore Karatzas, Ioanna Delladetsima, Stratigoula Sakellariou, Nikolaos Karidis, Gregory Kouraklis
Dimitrios Dimitroulis, Panagiotis Lainas, Petros Charalampoudis, Theodore Karatzas, Nikolaos Karidis, Gregory Kouraklis, 2nd Department of General Surgery, Laiko Hospital, University of Athens Medical School, 11527 Athens, Greece
Ioanna Delladetsima, Stratigoula Sakellariou, Department of Pathology, Laiko Hospital, University of Athens Medical School, 11527 Athens, Greece
Author contributions: Dimitroulis D and Lainas P designed, evaluated and wrote this work; Charalampoudis P, Karatzas T and Karidis N contributed to the discussion of the paper; Delladetsima I and Sakellariou S performed the pathological examination; and Kouraklis G supervised and critically revised the manuscript.
Correspondence to: Dimitroulis Dimitrios, MD, PhD, 2nd Department of General Surgery, Laiko Hospital, Agiou Thoma 17, 11527 Athens, Greece. dimitroulisdimitrios@yahoo.com
Telephone: +30-210-9803331 Fax: +30-210-7456972
Received: September 8, 2011
Revised: December 14, 2011
Accepted: October 22, 2012
Published online: November 27, 2012
Abstract

Focal nodular hyperplasia (FNH) and hepatocellular adenoma (HA) are both benign hepatocellular lesions, presenting mainly in women of childbearing age in non-cirrhotic, non-fibrotic livers. Simultaneous occurrence of these two lesions is extremely rare. We herein report a case of a young female without any predisposing risk factors who presented to our emergency department complaining of acute abdominal pain. Imaging studies revealed a 6 cm lesion in the right hepatic lobe and a 2.5 cm lesion in the left hepatic lobe, respectively. In view of the patient’s symptoms and lack of a confirmed diagnosis based on imaging, we performed a bisegmentectomy V-VI and a wedge resection of the lesion in segment III by laparotomy. Postoperative course was uneventful and the patient was discharged on the fourth postoperative day. The pathology report demonstrated an HA in segments V-VI and FNH in segment III, respectively. Six months later, the patient remains asymptomatic with normal liver function tests, ultrasound and magnetic resonance imaging follow-up. To our best knowledge, this is the first case to describe simultaneous occurrence of HA and FNH without the presence of any known risk factors for these entities. The uncertainty in diagnosis and acuteness of presenting symptoms were established criteria for prompt surgical intervention.

Keywords: Liver surgery, Liver disease, Hepatocellular adenoma, Focal nodular hyperplasia, Benign hepatic tumor