Sergi CM. Vitamin D supplementation for autoimmune hepatitis: A need for further investigation. World J Hepatol 2022; 14(1): 295-299 [PMID: 35126856 DOI: 10.4254/wjh.v14.i1.295]
Corresponding Author of This Article
Consolato M Sergi, MD, PhD, Chief, Anatomic Pathology Division, Pediatric Pathologist, Children’s Hospital of Eastern Ontario (CHEO), 401 Smyth Road, Ottawa K1H 8L1, ON, Canada. csergi@cheo.on.ca
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Letter to the Editor
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Hepatol. Jan 27, 2022; 14(1): 295-299 Published online Jan 27, 2022. doi: 10.4254/wjh.v14.i1.295
Vitamin D supplementation for autoimmune hepatitis: A need for further investigation
Consolato M Sergi
Consolato M Sergi, Anatomic Pathology Division, Children’s Hospital of Eastern Ontario (CHEO), University of Ottawa, Ottawa K1H 8L1, ON, Canada
Consolato M Sergi, Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton T6G 2B7, AB, Canada
Author contributions: Sergi CM drafted the manuscript following collection of the literature data.
Conflict-of-interest statement: No conflicts of interest with regard to this manuscript exist.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Consolato M Sergi, MD, PhD, Chief, Anatomic Pathology Division, Pediatric Pathologist, Children’s Hospital of Eastern Ontario (CHEO), 401 Smyth Road, Ottawa K1H 8L1, ON, Canada. csergi@cheo.on.ca
Received: September 4, 2021 Peer-review started: September 4, 2021 First decision: October 18, 2021 Revised: October 25, 2021 Accepted: December 23, 2021 Article in press: December 23, 2021 Published online: January 27, 2022
Abstract
Autoimmune hepatitis is a chronic liver disease harboring an autoimmune basis and progressive character. Despite still obscurity in etiology and pathogenesis, some evidence supports the importance of sustaining the immune system. Vitamin D is a lipo-soluble vitamin, which has been identified as decreased in our body. It is often due to the daily habit change and decrease of individual sun exposure due to the increase of the ultraviolet-induced potential melanocytic transformation. Here, we emphasize the importance of vitamin D supplementation in patients affected with liver disease.
Core Tip: Autoimmune hepatitis (AIH) is a chronic liver disease with an autoimmune basis. It can progress quite dramatically. The immune system may play a role in determining how this disease progresses. Vitamin D is key in supporting the immune system with or without vitamin deficiency. Here the vitamin D supplementation in patients affected with AIH is emphasized.
