Malnutrition in cirrhosis: More food for thought

Abstract

Malnutrition is highly prevalent in liver cirrhosis and its presence carries important prognostic implications. The clinical conditions and pathophysiological mechanisms that cause malnutrition in cirrhosis are multiple and interrelated. Anorexia and liver decompensation symptoms lead to poor dietary intake; metabolic changes characterised by elevated energy expenditure, reduced glycogen storage, an accelerated starvation response and protein catabolism result in muscle and fat wasting; and, malabsorption renders the cirrhotic patient unable to fully absorb or utilise food that has been consumed. Malnutrition is therefore a considerable challenge to manage effectively, particularly as liver disease progresses. A high energy, high protein diet is recognised as standard of care, yet patients struggle to follow this recommendation and there is limited evidence to guide malnutrition interventions in cirrhosis and liver transplantation. In this review, we seek to detail the factors which contribute to poor nutritional status in liver disease, and highlight complexities far greater than “poor appetite” or “reduced oral intake” leading to malnutrition. We also discuss management strategies to optimise nutritional status in this patient group, which target the inter-related mechanisms unique to advanced liver disease. Finally, future research requirements are suggested, to develop effective treatments for one of the most common and debilitating complications afflicting cirrhotic patients.

Keywords: Malnutrition, Cirrhosis, Liver transplantation, Chronic liver disease, Nutrition, Sarcopenia

Core Tip: Malnutrition is widespread in liver cirrhosis. This paper highlights the multifactorial aetiology of liver-related malnutrition, and details the complex challenges cirrhotic patients face in achieving nutritional targets. Although potentially modifiable, there are a scarcity of successful treatments hence the evidence base pertaining to nutritional interventions is surprisingly weak. Further research is required to bridge the gap between actual and ideal nutritional status in cirrhosis. If this goal can be realised, the potential impact on patient and clinical outcomes is immense.