Sibulesky L, Biggins SW, Pichler R. Protecting kidneys in liver transplant patients: A pathway to preventive interventions. World J Hepatol 2018; 10(9): 637-638 [PMID: 30310542 DOI: 10.4254/wjh.v10.i9.637]
Corresponding Author of This Article
Lena Sibulesky, MD, Associate Professor, Surgeon, Division of Transplant Surgery, Department of Surgery, University of Washington, 1959 NE Pacific Street, Box 356410, Seattle, WA 98195, United States. lenasi@uw.edu
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Letters To The Editor
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Hepatol. Sep 27, 2018; 10(9): 637-638 Published online Sep 27, 2018. doi: 10.4254/wjh.v10.i9.637
Protecting kidneys in liver transplant patients: A pathway to preventive interventions
Lena Sibulesky, Scott W Biggins, Raimund Pichler
Lena Sibulesky, Division of Transplant Surgery, Department of Surgery, University of Washington, Seattle, WA 98195, United States
Scott W Biggins, Division of Gastroenterology and Hepatology, Department of Medicine, University of Washington, Seattle, WA 98195, United States
Raimund Pichler, Division of Nephrology, Department of Medicine, University of Washington, Seattle, WA 98195, United States
Author contributions: Sibulesky L, Biggins SW and Pichler R wrote this letter.
Conflict-of-interest statement: There are no conflicts of interest.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Lena Sibulesky, MD, Associate Professor, Surgeon, Division of Transplant Surgery, Department of Surgery, University of Washington, 1959 NE Pacific Street, Box 356410, Seattle, WA 98195, United States. lenasi@uw.edu
Telephone: +1-206-5987797 Fax: +1-206-5984287
Received: May 16, 2018 Peer-review started: May 16, 2018 First decision: May 24, 2018 Revised: May 30, 2018 Accepted: June 28, 2018 Article in press: June 28, 2018 Published online: September 27, 2018
Abstract
Acute kidney injury (AKI) is a frequent postoperative complication after liver transplantation. The etiology is multifactorial, including perioperative renal status, surgery related events, and postoperative immunosuppression therapy. The role of renal hypoperfusion and hepatic ischemia-reperfusion injury as causes of early AKI are now being increasingly recognized. Further studies should focus on therapies that would attenuate this injury.
Core tip: Acute kidney injury early post liver transplantation is a major cause of morbidity and mortality. The etiology is multifactorial. The renal hypoperfusion and hepatic ischemia-reperfusion injury are being increasingly recognized. Further studies need to focus on therapies that would attenuate this injury.
