Review
Copyright ©The Author(s) 2016.
World J Stem Cells. Oct 26, 2016; 8(10): 332-341
Published online Oct 26, 2016. doi: 10.4252/wjsc.v8.i10.332
Table 1 Human lung resident stem/progenitor cells
Cell typeCell markers
Tracheal basal epithelial cellsNGFR+/ITGA6+
Type II alveolar cellsHTII-280+
Airway epithelial cellsCD151+/TF+
Airway epithelial cellsSP/CD45-
Lung epithelial cellsc-kit+ (CD117)
Lung epithelial cellsEcad/Lgr6+
L-MSCsCD73+/CD90+/CD105+
Table 2 Circulating endothelial progenitor cells studies in patients with obstructive sleep apnea syndrome
Ref.Study designEPCs phenotypeOSAS effect on EPCs number
de la Peña et al[60]Adults, men, flow cytometryCD34+VEGFR2+Reduced number
Jelic et al[61]Adults, both genders, flow cytometryCD34+CD133+VEGFR2+Reduced number
Jelic et al[62]Adults, both genders, flow cytometryCD34+CD133+VEGFR2+Reduced number
Murri et al[63]Adults, both genders, flow cytometryCD45-CD34+CD133+VEGFR2+Reduced number
Kheirandish-Gozal et al[64]Children, both genders, flow cytometryCD34+CD133+VEGFR2+Reduced number
Martin et al[65]Adults, both genders, flow cytometryCD34+CD133+CD45dimUnchanged number
Yun et al[66]Adults, both genders, endothelial colony forming units assay-Unchanged number
Simpson et al[67]Adults, men, flow cytometryCD34+KDR+Unchanged number
CD45-CD34+KDR+
Kizawa et al[68]Adults, men, flow cytometryCD133+CD34+CD202b+CD45-Increased number
Lui et al[69]Adults, both genders, flow cytometryCD34+Increased number
Chou et al[70]Adults, both genders, flow cytometryCD34+Increased number
Table 3 Circulating endothelial progenitor cells studies in patients with obstructive sleep apnea syndrome treated by continuous positive airway pressure
Ref.Study designEPCs phenotypeCPAP effect on EPCs number
Jelic et al[61]Adults, both genders, flow cytometryCD34+CD133+VEGFR2+Normalized after 4 wk of CPAP
Jelic et al[62]Adults, both genders, flow cytometryCD34+CD133+VEGFR2+Normalized after 4 wk of CPAP
Murri et al[63]Adults, both genders, flow cytometryCD45-CD34+CD133+VEGFR2+Values returned to control values after 1 mo of CPAP
Simpson et al[67]Adults, men, flow cytometryCD34+KDR+ CD34+KDR+CD45-Unchanged
Kizawa et al[68]Adults, men, flow cytometryCD133+CD34+CD202b+CD45-Values decreased after 12 wk of CPAP treatment
Chou et al[70]Adults, both genders, flow cytometryCD34+Mobilization ratio in patients with OSAS tended to decline