Stem cell therapy for retinal diseases

Table 1 Clinical trials using stem cell for retinal therapy currently registered on ClinicalTrials.gov

Injury or disorder	Sponsor	Type or source of cells	Delivery	Identification
Stargadt’s, AMD (GA)	Advanced cell technology, recruiting	hESC RPE	Subretinal transplantation	NCT01469832
AMD (GA), RP, ischaemic retinopathy	University of Sao Paulo recruiting	BMSC	Intravitreal injection	NCT01518127 NCT01560715 NCT01518842
AMD	Pfizer, ongoing	hESC RPE	Subretinal transplantation	NCT01691261
AMD (GA), RP, RVO, DR	UC Davis recruiting	BMSC	Intravitreal injection	NCT01736059
Stargadt’s, Fundus Flavimaculatus, Juvenile Macular Dystrophy	Advanced cell technology, recruiting	hESC RPE	Subretinal transplantation	NCT01469832
Retinal and optic nerve damage	Retinal associates of South Florida, recruiting	BMSC	Retrobulbar, subtenon and intravenous injection	NCT01920867
AMD	Advanced cell technology, recruiting	hESC RPE	Subretinal injection	NCT01344993
AMD	Al-Azhar University, recruiting	BMSC	Intravitreal injection	NCT02016508
RP	Chaitanya Hospital, recruiting	MSC	Not informed	NCT01914913
RP	Mahidol University, recruiting	MSC	Intravitreal injection	NCT01531348
Myopic Macular Degeneration	UC Los Angeles, ongoing	hESC RPE	Subretinal transplantation	NCT02122159
Best disease	Mayo Clinic, recruiting	iPSC RPE	Not informed	NCT02162953
AMD	CHA Bio and Diostech, recruiting	hESC RPE	Subretinal transplantation	NCT01674829
Stargadt’s	Advanced cell technology, recruiting	hESC RPE	Subretinal transplantation	NCT01345006
Stargadt’s	CHA Bio and Diostech, recruiting	hESC RPE	Subretinal transplantation	NCT01625559

Legends[29]. AMD: Age related macular degeneration; GA: Geographic atrophy; RVO: Retinal vein occlusion; DR: Diabetic retinopathy; SC: Stem cells; hESC RPE: Human embryonic stem cells derived RPE; iPSC: Induced pluripotent stem cells; BMSC: Boné marrow stem cells; RP: Retinitis pigmentosa; MSC: Mesenchymal stem cells.