Review
Copyright ©The Author(s) 2021.
World J Stem Cells. May 26, 2021; 13(5): 342-365
Published online May 26, 2021. doi: 10.4252/wjsc.v13.i5.342
Table 1 Summary of the microRNAs influencing the odontogenic/osteogenic differentiation of dental mesenchymal stem cells
Ref.MicroRNACell typeSignaling pathway or targetsOutcome
Zhan et al[112], 2018miR-143-5pDPSCsOPG/RANKLDownregulation promoted odontoblastic differentiation
Yang et al[113], 2020miR-143-3pDPSCsOPG/RANKLDownregulation promoted odontogenic differentiation
Wang et al[114], 2019miR-143-5pDPSCsMAPK14Downregulation promoted odontoblastic differentiation
Yu et al[115], 2019miR-488DPSCsMAPK1Downregulation enhanced odontoblastic differentiation
Wang et al[116], 2020miR-125a-3pDPSCsFynRegulated odontoblastic differentiation in an inflammation model
Yuan et al[117], 2019miR-let-7c-5pInflamed human DPSCs-Restored the osteogenic differentiation
Huang et al[118], 2019miR-223-3pInflamed human DPSCs-Increased the proteins levels of DSPP and DMP-1
Sun et al[119], 2017miR-140-5pDPSCs-Inhibited odontoblastic differentiation after LPS treated
Liu et al[120], 2019miR-508-5pDPSCsGPNMBInhibited odontogenic differentiation
Xu et al[121], 2018miR-21DPSCsSTAT3Downregulation caused the decreasing expression of DMP-1 and DSPP
Qiu et al[122], 2019miR-146a-5pSTRO-1 + human DPSCs-Promoted osteo/odontogenic differentiation
Zhang et al[123], 2018miR-143DPSCsTNF-α/NF-κBSuppressed the osteogenic differentiation
Yao et al[124], 2019miR-215, miR-219a-1-3pDPSCsHspB8Inhibited the osteogenic differentiation
Wei et al[125], 2017miR-21PDLSCsSmad5Inhibited osteogenesis
Li et al[126], 2019miR-24-3pPDLSCsSmad5Inhibited osteogenic differentiation
Wei et al[127], 2015miR-21PDLSCsACVR2BPerformed a positive function in mediating the stretch-induced osteogenic differentiation
Yao et al[128], 2017; Cao et al[129], 2017miR-214PDLSCsATF4, Wnt/β-cateninDownregulation decreased the osteogenic differentiation
Bao et al[130], 2019miR-148aPDLSCs-Downregulation rescued the inhibition of osteogenesis triggered by LPS stimulation
Yan et al[131], 2017miR-22PDLSCsHDAC6Promoted osteogenesis
Li et al[132], 2018miR-17PDLSCsHDAC9Promoted osteogenesis in an inflammation condition
Xu et al[133], 2019miR-132PDLSCsGDF5, NF-κBInhibited the osteogenesis
Zhen et al[134], 2017miR-31PDLSCsSatb2Took part in the high glucose-suppressed osteogenic differentiation
Wan et al[135], 2012miR-34aHuman dental papilla cells-Increased the expression of DSPP and decreased the expression of ALP
Sun et al[136], 2014miR-34aSCAPs-Upregulated odonto/osteogenic markers
Wang et al[137], 2018miR hsa-let-7bSCAPsMMP1Suppressed the odonto/osteogenic differentiation
Dernowsek et al[138], 2017miR-450a-5p,miR-28-5pSHED-Supported the osteogenesis
Klingelhöffer et al[139], 2016miR-101DFSCs-Enhanced the osteogenic differentiation
Han et al[140], 2019miR-3940-5pGMSCs-Promoted the osteo/dentinogenic differentiation
Table 2 Summary of the long noncoding RNAs influencing the odontogenic/osteogenic differentiation of dental mesenchymal stem cells
Ref.LncRNACell typeSignaling pathway or targetsOutcome
Liu et al[141], 2020lncRNA SNHG7DPSCsmiR-1226-3p, miR-210-5pDownregulation inhibited osteo/odontogenic differentiation
Chen et al[142], 2020lncRNA-G043225DPSCsmiR-588, FBN1Positively regulated odontoblastic differentiation
Zhong et al[145], 2019lncRNA CCAT1DPSCsmiR-218Overexpression promoted odontogenic differentiation
Zeng et al[146], 2018lncRNA H19DPSCsDLX3Upregulation enhanced odontogenic differentiation
Shi et al[143], 2019lncRNA STLDPSCs-Knockdown inhibited osteogenesis
Tao et al[147], 2019lncRNA XISTDPSCs-Downregulation inhibited osteogenic differentiation
Zheng et al[149], 2018lncRNA MEG8, lncRNA MIR22HGPDLSCs-Downregulation suppressed osteogenic differentiation
Liu et al[150], 2019; Deng et al[151], 2018lncRNA MEG3PDLSCsmiR-27a-3p/IGF1 axis, Wnt/β-cateninKnockdown inhibited osteogenesis
Wang et al[152], 2016lncRNA-POIRPDLSCsmiR-182Enhanced osteogenic differentiation
Xu et al[153], 2019lncRNA-TWIST1PDLSCsTWIST1Improved osteogenic differentiation
Jia et al[154], 2019lncPCAT1PDLSCs-Reversed the suppression effect of osteogenesis caused by miR-106a-5p overexpression
Huang et al[155], 2020lncRNA FER1L4PDLSCsmiR-874-3pPromoted osteogenic differentiation
Feng et al[156], 2020lncRNA XISTPDLSCsmiR-214-3pEnhanced osteogenic differentiation
He et al[160], 2018lncRNA TUG1PDLSCslin-28 homolog AImproved osteogenic differentiation
Wang et al[161], 2020lncRNA DANCRPDLSCs-Positively regulated osteogenic differentiation
Li et al[162], 2019lncRNA H19SCAPslncRNA-H19/miR-141/SPAG9/MAPKPromoted the osteo/odontogenesis
Jia et al[157], 2016; Jia et al[158], 2015; Peng et al[159], 2018lncRNA ANCRDPSCs, PDLSCs, SCAPsWnt, lncRNA-ANCR/miR-758/Notch2 (PDLSCs)Downregulation facilitated osteogenic differentiation