Current understanding of mesenchymal stem cells in liver diseases

doi:10.4252/wjsc.v13.i9.1349

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Sep 26, 2021 (publication date) through Apr 17, 2024

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World Journal of Stem Cells

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1948-0210

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Stem Cells. Sep 26, 2021; 13(9): 1349-1359
Published online Sep 26, 2021. doi: 10.4252/wjsc.v13.i9.1349

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Figure 1 The mechanism of mesenchymal stem cells in liver diseases. A: Mesenchymal stem cell (MSCs) differentiate into hepatocyte-like cells both in vitro and in vivo; B: MSCs modulate effector cells of innate and adaptive immune systems; C: MSCs alleviate liver fibrosis. MSC: Mesenchymal stem cell; UC-MSC: Human umbilical cord-derived MSC; HGF: Hepatocyte growth factor; EGF: Epidermal growth factor; FGF: Fibroblast growth factor; OSM: Oncostatin M; HLCs: Hepatocyte-like cells; ALB: Albumin; AFP: Alpha-fetoprotein; CK18: Cytokeratin 18; CK19: Cytokeratin 19; DC: Dendritic cell; M1: M1 macrophage; M2: M1 macrophage; IL-12: Interleukin 12; PGE2: Prostaglandin E2; IDO: Indoleamine 2,3-dioxygenase; MMP: Matrix metalloproteinases; TGF-β1: Transforming growth factor-β1; Th17: T helper cells 17; Treg: Regulatory T cells; HSC: Hepatic stellate cell; IL-10: Interleukin 10; TNFα: Tumor necrosis factor α; MFGE8: Milk factor globule EGF 8; ECM: Extracellular matrix.

Citation: Wu MC, Meng QH. Current understanding of mesenchymal stem cells in liver diseases. World J Stem Cells 2021; 13(9): 1349-1359
URL: https://www.wjgnet.com/1948-0210/full/v13/i9/1349.htm
DOI: https://dx.doi.org/10.4252/wjsc.v13.i9.1349