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World J Stem Cells. Sep 26, 2021; 13(9): 1349-1359
Published online Sep 26, 2021. doi: 10.4252/wjsc.v13.i9.1349
Current understanding of mesenchymal stem cells in liver diseases
Mu-Chen Wu, Qing-Hua Meng
Mu-Chen Wu, Qing-Hua Meng, Department of Medical Oncology,You An Hospital, Capital Medical University, Beijing 100069, China
Author contributions: Wu MC and Meng QH conceived and outlined the concept; Wu MC reviewed the literature and drafted the manuscript; Meng QH made critical revisions to the manuscript; all authors approved the final version of the manuscript.
Supported by the Municipal Natural Science Foundation of Beijing, China, No. 7192085.
Conflict-of-interest statement: The authors declare no conflicts of interest for this manuscript.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Qing-Hua Meng, MD, Chief Physician, Professor, Department of Medical Oncology, You An Hospital, Capital Medical University, No. 8 Youanmen Wai, Fengtai District, Beijing 100069, China. meng_qh0805@ccmu.edu.cn
Received: March 20, 2021
Peer-review started: March 20, 2021
First decision: June 16, 2021
Revised: July 1, 2021
Accepted: August 25, 2021
Article in press: August 25, 2021
Published online: September 26, 2021
Core Tip

Core Tip: Liver diseases are major threats that endanger public health globally. Mesenchymal stem cell (MSC) transplantation has been proposed as an attractive therapeutic option for liver diseases due to their differentiation potential, immune-modulatory properties, and paracrine release. Here, we will summarize the molecular mechanisms underlying therapeutic effects of MSCs on liver diseases and clinical trials in MSC-based therapies.