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World J Stem Cells. Jun 26, 2017; 9(6): 89-97
Published online Jun 26, 2017. doi: 10.4252/wjsc.v9.i6.89
Skeletal muscle generated from induced pluripotent stem cells - induction and application
Yuko Miyagoe-Suzuki, Shin’ichi Takeda
Yuko Miyagoe-Suzuki, Shin’ichi Takeda, Department of Molecular Therapy, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Tokyo 187-8502, Japan
Author contributions: Miyagoe-Suzuki Y primarily wrote the manuscript; Takeda S supervised the writing.
Supported by The Program for Intractable Diseases Research utilizing Disease-specific iPS cells (Japan Agency for Medical Research and Development: AMED), No. 15652069; Projects for Technological Development (K1), from the Research Center Network for Realization of Regenerative Medicine (AMED); Intramural Research Grants for Neurological and Psychiatric Disorders of NCNP, No. 27-7; Grant-in-Aid for Scientific Research (C) (Japan Society for the Promotion of Science), No. 16744921.
Conflict-of-interest statement: There is no conflict of interest.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Yuko Miyagoe-Suzuki, MD, PhD, Section Chief, Department of Molecular Therapy, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4-1-1 Ogawa-higashi, Kodaira, Tokyo 187-8502, Japan. miyagoe@ncnp.go.jp
Telephone: +81-42-3461720 Fax: +81-42-3461750
Received: January 29, 2017
Peer-review started: February 13, 2017
First decision: March 27, 2017
Revised: May 9, 2017
Accepted: May 18, 2017
Article in press: May 19, 2017
Published online: June 26, 2017
Core Tip

Core tip: Skeletal muscle cells induced from patient induced pluripotent stem cells (iPSCs) are useful for the study of pathogenesis and drug development. The derivation of mature myofibers is required for disease modeling. On the other hand, human iPSCs from healthy donors are likely to be a cell source for cell therapy. For safe cell transplantation, non-oncogenic cells are needed.