Copyright ©The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Stem Cells. Apr 26, 2016; 8(4): 170-184
Published online Apr 26, 2016. doi: 10.4252/wjsc.v8.i4.170
Retinoblastoma tumor suppressor functions shared by stem cell and cancer cell strategies
Susumu Kohno, Shunsuke Kitajima, Nobunari Sasaki, Chiaki Takahashi
Susumu Kohno, Chiaki Takahashi, Division of Oncology and Molecular Biology, Cancer Research Institute, Kanazawa University, Kanazawa, Ishikawa 920-1192, Japan
Shunsuke Kitajima, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, United States
Nobunari Sasaki, Department of Pharmacy, Graduate School of Medicine, Keio University, Tokyo 106-0016, Japan
Author contributions: All authors wrote the manuscript.
Supported by The Funding Program for Next Generation World-Leading Researchers (NEXT), Grant-in-Aid for Scientific Research (MEXT), Naito Foundation, Daiichi-Sankyo Foundation for Life Science, Hokkoku Foundation for Cancer Research, and IMSUT Joint Research Project.
Conflict-of-interest statement: Authors declare no conflict of interests for this article.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Correspondence to: Chiaki Takahashi, MD, PhD, Division of Oncology and Molecular Biology, Cancer Research Institute, Kanazawa University, 13-1 Takara-machi, Kanazawa, Ishikawa 920-1192, Japan.
Telephone: +81-76-2646750 Fax: +81-76-2344521
Received: October 28, 2015
Peer-review started: November 3, 2015
First decision: December 4, 2015
Revised: December 30, 2015
Accepted: February 14, 2016
Article in press: February 16, 2016
Published online: April 26, 2016
Core Tip

Core tip: Carcinogenic transformation of somatic cells resembles nuclear reprogramming toward the generation of pluripotent stem cells. The retinoblastoma tumor suppressor product retinoblastoma (RB) seems to be critically involved in both events in highly complicated manners. This review covers recent findings on RB functions related to stem cells and stem cell-like behaviors of cancer cells.