Published online Apr 26, 2016. doi: 10.4252/wjsc.v8.i4.158
Peer-review started: June 20, 2015
First decision: August 14, 2015
Revised: September 17, 2015
Accepted: February 14, 2016
Article in press: February 16, 2016
Published online: April 26, 2016
Core tip: Mucosal-associated invariant T (MAIT) cells, a novel innate-like T cell subset abundant in humans, play a pivotal role in immune-dysregulated diseases. However, MAIT cells are quite rare in laboratory mice and show poor proliferation in vitro. This makes it difficult to delineate their physiological functions in health and disease. Therefore, we developed a method to generate human MAIT cells from induced pluripotent stem cells [redifferentiation of MAIT (reMAIT) cells]. Given that reMAIT cells harbor characteristics quasi-identical to those found in MAIT cells from human peripheral blood, they will be useful to model human diseases in animals.