Copyright ©The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Stem Cells. Apr 26, 2016; 8(4): 136-157
Published online Apr 26, 2016. doi: 10.4252/wjsc.v8.i4.136
Migration of bone marrow progenitor cells in the adult brain of rats and rabbits
Donnahue Dennie, Jean-Pierre Louboutin, David S Strayer
Donnahue Dennie, Jean-Pierre Louboutin, Section of Anatomy, Department of Basic Medical Sciences, University of the West Indies, Mona Campus, Kingston 7, Jamaica
David S Strayer, Department of Cell Biology, Anatomy and Pathology, Thomas Jefferson University, Philadelphia, PA 19107, United States
Author contributions: Dennie D and Louboutin JP contributed equally to writing the paper; Strayer DS supervised the work.
Conflict-of-interest statement: There is no conflict of interest.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Correspondence to: Jean-Pierre Louboutin, MD, PhD, Section of Anatomy, Department of Basic Medical Sciences, University of the West Indies, Mona Campus, West Road, Kingston 7, Jamaica.
Telephone: +876-3680554
Received: June 2, 2015
Peer-review started: June 7, 2015
First decision: July 6, 2015
Revised: October 19, 2015
Accepted: February 14, 2016
Article in press: February 16, 2016
Published online: April 26, 2016
Core Tip

Core tip: It was previously thought that the development of new neurons did not take place in the adult brain of higher vertebrates. There has been substantial progress in understanding neurogenesis in the adult brain during the last decade, showing that neural progenitor cells can induce neurogenesis, mainly in three areas: Subventricular zone, subgranular zone of the hippocampal dentate gyrus, and olfactory bulb. More recently, it has been shown that bone marrow progenitor cells can participate in neurogenesis in the adult brain. In this review, we discuss the mechanisms of the migration, differentiation, and maturation of bone marrow progenitor cells in the adult brain. We also consider the increase of adult neurogenesis following experimental seizures, provided that neuroinflammation is decreased by reducing the expression of chemokines, and consequently the related migration of inflammatory cells into the brain parenchyma.