Published online Aug 26, 2015. doi: 10.4252/wjsc.v7.i7.1039
Peer-review started: November 26, 2014
First decision: January 8, 2015
Revised: May 18, 2015
Accepted: July 16, 2015
Article in press: July 19, 2015
Published online: August 26, 2015
Core tip: High-dose therapy (HDT) followed by autologous stem cell transplantation (ASCT) is considered the golden standard for the vast majority of patients with both Hodgkin and non-Hodgkin lymphoma, who either relapse or never attain a remission. However, several questions about HDT/ASCT still remain unanswered, also comprising, but not limited to, its role in newly diagnosed patients with advanced stage disease. The incorporation of novel drugs in both salvage and conditioning regimens has recently revitalized the HDT/ASCT area, with several phase I-II trials performed during the last 5 years. This review will focus on the most recent data regarding HDT/ASCT in lymphomas.