Copyright
©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Stem Cells. Jul 26, 2015; 7(6): 945-955
Published online Jul 26, 2015. doi: 10.4252/wjsc.v7.i6.945
Published online Jul 26, 2015. doi: 10.4252/wjsc.v7.i6.945
New insights into the epigenetic control of satellite cells
Viviana Moresi, Nicoletta Marroncelli, Sergio Adamo, Department of Anatomical, Histological, Forensic and Orthopaedic Sciences, Sapienza University of Rome, 00161 Rome, Italy
Author contributions: Moresi V, Marroncelli N and Adamo S wrote the paper.
Supported by The following grants: SA: Sapienza University 2012 (# C26A125ENW) and PRIN 2012 (# 2012N8YJC3); NM: Sapienza University “Avvio alla ricerca” 2014; and VM: EU Marie Curie “Muscle repair-Mdx”, Italian Ministry of Instruction, University and Research FIRB project and Italian Ministry of Health “Ricerca finalizzata” grants.
Conflict-of-interest statement: The authors declare no conflicts of interest.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Sergio Adamo, MD, Department of Anatomical, Histological, Forensic and Orthopaedic Sciences, Sapienza University of Rome, Via Antonio Scarpa 16, 00161 Rome, Italy. sergio.adamo@uniroma1.it
Telephone: +39-6-49766756 Fax: +39-6-4462854
Received: November 26, 2014
Peer-review started: November 26, 2014
First decision: December 12, 2014
Revised: February 12, 2015
Accepted: May 8, 2015
Article in press: May 11, 2015
Published online: July 26, 2015
Peer-review started: November 26, 2014
First decision: December 12, 2014
Revised: February 12, 2015
Accepted: May 8, 2015
Article in press: May 11, 2015
Published online: July 26, 2015
Core Tip
Core tip: Skeletal muscle needs to efficiently respond to internal and external stimuli, and satellite cells (SCs), the stem cells of muscle, play key roles in the preservation of muscle mass under both physiological and pathological conditions. Epigenetic pathways participate in coordinating the precise time-dependent expression of different subsets of myogenic genes in SCs. Thus, these pathways represent promising targets for therapeutic interventions. In this review, we focus on the epigenetic changes mediated by histone modifications - methylation or acetylation - and by noncoding mRNAs throughout SC differentiation.