Copyright
©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Stem Cells. Jun 26, 2015; 7(5): 815-822
Published online Jun 26, 2015. doi: 10.4252/wjsc.v7.i5.815
Published online Jun 26, 2015. doi: 10.4252/wjsc.v7.i5.815
Stem cell applications for pathologies of the urinary bladder
Noha A Mousa, Zewail University of Science and Technology 1 Center Of Excellence for Stem Cells and Regenerative Medicine (CESC), Giza 12588, Egypt
Hisham A Abou-Taleb, Department of Gynecology and Obstetrics, Assiut University, Assiut 71515, Egypt
Hazem Orabi, Department of Urology, Assiut University, Assiut 71515, Egypt
Hazem Orabi, Department of Surgery, Laval University, Québec City G1J 1Z4, Canada
Hazem Orabi, Centre de recherche en organogénèse expérimentale de l’Université Laval/LOEX, Division of Regenerative Medicine, CHU de Québec Research Centre, Québec City G1V 0A6, Canada
Author contributions: Mousa NA wrote the first draft of the manuscript and contributed to final drafting and editing; Abou-Taleb HA contributed to manuscript writing; and Orabi H contributed to planning of the article, writing the manuscript and critical revision.
Conflict-of-interest: The authors have no conflict of interest to declare.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Hazem Orabi, MD, PhD, Department of Surgery, Laval University, Québec City G1J 1Z4, Québec, Canada. hazem.orabi.1@ulaval.ca
Telephone: +1-418-9908255-1774 Fax: +1-418-9908248
Received: November 30, 2014
Peer-review started: December 2, 2014
First decision: January 20, 2015
Revised: February 5, 2015
Accepted: April 1, 2015
Article in press: April 7, 2015
Published online: June 26, 2015
Peer-review started: December 2, 2014
First decision: January 20, 2015
Revised: February 5, 2015
Accepted: April 1, 2015
Article in press: April 7, 2015
Published online: June 26, 2015
Core Tip
Core tip: This article reviews the current status of the stem cell based therapies in the field of treating urinary tract pathologies. We provide a particular focus on bladder reconstruction models that were based on stem cellular therapies. Stress incontinence and voiding dysfunction represent common clinical problems that could benefit from advancing the stem cell field. A brief highlight is given to bladder cancer stem cells and therapeutic value that could arise from controlling their behavior. We also note the pressing need for more robust regulations and quality guidelines to prevent the transfer of research findings prematurely into routine clinical practice.