Copyright ©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Stem Cells. May 26, 2015; 7(4): 745-756
Published online May 26, 2015. doi: 10.4252/wjsc.v7.i4.745
Systems biology approach to developing S2RM-based “systems therapeutics” and naturally induced pluripotent stem cells
Greg Maguire, Peter Friedman
Greg Maguire, Peter Friedman, SRM Living Foundry, BioRegenerative Sciences, Inc., San Diego, CA 92014, United States
Author contributions: Maguire G wrote the paper; Friedman P edited the paper.
Conflict-of-interest: None.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Correspondence to: Greg Maguire, PhD, SRM Living Foundry, BioRegenerative Sciences, Inc., 2658 Del Mar Heights Rd #416, San Diego, CA 92014, United States.
Telephone: +1-858-4137272 Fax: +1-877-8929995
Received: August 29, 2014
Peer-review started: August 30, 2014
First decision: November 14, 2014
Revised: November 25, 2014
Accepted: March 16, 2015
Article in press: March 18, 2015
Published online: May 26, 2015
Core Tip

Core tip: A fundamentally new type of therapeutic, namely “systems therapeutic,” can be realized by reverse engineering the mechanisms of the stem cell released molecules (SRM) processes. Recent data demonstrates that the composition of the SRM is different for each type of stem cell, as well as for different states of each cell type. Although systems biology has been successfully used to analyze multiple pathways, the approach is often used to develop a small molecule interacting at only one pathway in the system. A new model is emerging in biology where systems biology is used to develop a new technology acting at multiple pathways called “systems therapeutics”.