Published online May 26, 2015. doi: 10.4252/wjsc.v7.i4.711
Peer-review started: August 28, 2014
First decision: September 4, 2014
Revised: October 2, 2014
Accepted: February 4, 2015
Article in press: February 9, 2015
Published online: May 26, 2015
Core tip: Loss of hair follicles caused by injuries or pathologies affects the patients’ psychological well-being and endangers inherent functions of the skin. Different experimental strategies and approaches to obtain mature hair follicles have been designed based upon current knowledge of the epithelial and dermal cells involved in embryonic hair generation and adult hair cycling, and in the epithelial-mesenchymal interactions among them. This review summarizes the current advances in hair follicle neogenesis and regeneration, with emphasis on those involving neogenesis of hair follicles in adults from isolated cells and tissue engineering as well as an analysis on patent trends in this field.