Published online May 26, 2015. doi: 10.4252/wjsc.v7.i4.681
Peer-review started: December 14, 2014
First decision: December 26, 2014
Revised: January 16, 2015
Accepted: February 9, 2015
Article in press: February 11, 2015
Published online: May 26, 2015
Core tip: Several papers regarding the osteogenic differentiation potential of cells isolated from amniotic fluid have been published so far with particular attention to various feasible approaches to improving differentiation both in vitro and in vivo. Hence, an overview is necessary on the data reported up to now in order to understand the potential of amniotic fluid-derived cells in bone regenerative medicine. This review takes a general look at the current state-of-the-art of the osteogenic ability of amniotic fluid-derived cells and the different strategies available to improve bone regeneration.