Published online May 26, 2015. doi: 10.4252/wjsc.v7.i4.669
Peer-review started: January 31, 2015
First decision: February 7, 2015
Revised: March 13, 2015
Accepted: April 10, 2015
Article in press: April 14, 2015
Published online: May 26, 2015
Core tip: This article reviews the current body of knowledge on biotechnological applications of spermatogonial stem cells (SSCs). SSCs are the founding adult germ stem cells of the sperm producing process spermatogenesis. SSCs belong to the male germline and can be expanded in vitro in several species. Through mechanisms not fully understood they can derive pluripotent stem cells in vitro. Thus, they can be genetically modified with some advantages over embryonic stem cell-based technologies. SSCs can be transplanted to homotopical or ectopical locations, offering great potentials in fertility related issues and regenerative clinical applications in domestic or wild animals and men.