Copyright
©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Stem Cells. Apr 26, 2015; 7(3): 641-648
Published online Apr 26, 2015. doi: 10.4252/wjsc.v7.i3.641
Published online Apr 26, 2015. doi: 10.4252/wjsc.v7.i3.641
Current focus of stem cell application in retinal repair
María L Alonso-Alonso, Girish K Srivastava, Instituto Universitario de Obtalmobiología Aplicada (IOBA), Universidad de Valladolid, 47011 Valladolid, Spain
Girish K Srivastava, Centro en Red de Medicina Regenerativa y Terapia Celular de Castilla y León, 47011 Valladolid, Spain
Author contributions: Alonso-Alonso ML and Srivastava GK contributed equally to this work.
Supported by Partially supported by grants from Junta de Castilla y León, No. VA386A12-2; and the Centro en Red de Medicina Regenerativa y Terapia Celular de la Junta de Castilla y León, 47011 Valladolid, Spain; a scholarship to María L Alonso-Alonso from the Consejería de Educación de la Junta de Castilla y León and the Fondo Social Europeo.
Conflict-of-interest: The authors have no conflicts of interest to disclose.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Girish K Srivastava, PhD, Principal Investigator, Instituto Universitario de Oftalmobiologia Aplicada (IOBA), Universidad de Valladolid, Campus Universitario Miguel Delibes, Paseo de Belén, 17, 47011 Valladolid, Spain. girish@ioba.med.uva.es
Telephone: +34-983-184753 Fax: +34-983-184762
Received: October 1, 2014
First decision: October 28, 2014
Revised: November 6, 2014
Accepted: January 15, 2015
Article in press: January 19, 2015
Published online: April 26, 2015
Processing time: 203 Days and 12.5 Hours
First decision: October 28, 2014
Revised: November 6, 2014
Accepted: January 15, 2015
Article in press: January 19, 2015
Published online: April 26, 2015
Processing time: 203 Days and 12.5 Hours
Core Tip
Core tip: Several retinal diseases are based on different retinal cell layer degenerations. Some of them have no treatment to date. Advances in stem cell therapy are considered a realistic option. In contrast to the early stage, the late stage of these diseases requires treatment techniques based on cell replacement. Currently, a few are in clinical trials using the sources of embryonic stem cells, induced pluripotent stem cells and adipose derived mesenchymal stem cells. The focus is mainly to enhance the output of these techniques, securing faster implementation and patient safety. Nevertheless, there are many challenges still to resolve.