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©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Stem Cells. Mar 26, 2015; 7(2): 300-314
Published online Mar 26, 2015. doi: 10.4252/wjsc.v7.i2.300
Published online Mar 26, 2015. doi: 10.4252/wjsc.v7.i2.300
Imprinted Zac1 in neural stem cells
Guillaume Daniel, Udo Schmidt-Edelkraut, Dietmar Spengler, Anke Hoffmann, Max Planck Institute of Psychiatry, Translational Research, 80804 Munich, Germany
Author contributions: Daniel G, Schmidt-Edelkraut U, Spengler D and Hoffmann A jointly contributed to this paper.
Supported by Max Planck Institute of Psychiatry.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Dietmar Spengler, MD, Max Planck Institute of Psychiatry, Translational Research, Kraepelinstrasse 2-10, 80804 Munich, Germany. spengler@mpipsykl.mpg.de
Telephone: +49-89-30622587 Fax: +49-89-30622605
Received: July 25, 2014
Peer-review started: July 25, 2014
First decision: August 28, 2014
Revised: September 24, 2014
Accepted: November 17, 2014
Article in press: November 19, 2014
Published online: March 26, 2015
Peer-review started: July 25, 2014
First decision: August 28, 2014
Revised: September 24, 2014
Accepted: November 17, 2014
Article in press: November 19, 2014
Published online: March 26, 2015
Core Tip
Core tip: Both neural stem cells (NSCs) and imprinted genes participate in the same developmental processes. Here, we will explore the possibility that these two processes actually interact with each other. We will exemplarily consider the role of single imprinted genes in NSC biology based on their functional relationship to the imprinted gene Zac1, which is itself at the focus of this review due to its role in directing neuronal vs astroglial differentiation of NSCs and as a central hub of an imprinted gene network comprising genes important to NSC biology.