Minireviews
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World J Stem Cells. Sep 26, 2014; 6(4): 467-472
Published online Sep 26, 2014. doi: 10.4252/wjsc.v6.i4.467
Human induced pluripotent stem cells: A new source for brown and white adipocytes
Anne-Laure Hafner, Christian Dani
Anne-Laure Hafner, Christian Dani, Faculté de Médecine, UMR CNRS/INSERM, Université Nice Sophia Antipolis, iBV, 06107 Nice Cedex 2, France
Author contributions: Hafner AL and Dani C solely contributed to this review.
Supported by Fondation ARC and ANRS
Correspondence to: Dr. Christian Dani, Faculté de Médecine, UMR CNRS/INSERM, Université Nice Sophia Antipolis, iBV, 28 Avenue de Valombrose, 06107 Nice Cedex 2, France. dani@unice.fr
Telephone: +33-04-93377647 Fax: +33-04-93377058
Received: July 22, 2014
Revised: August 25, 2014
Accepted: August 30, 2014
Published online: September 26, 2014
Core Tip

Core tip: In this mini-review, we summarized the potential of human induced pluripotent stem cells to generate white and brown adipocytes and we discussed their therapeutic capacities for obesity and lipodystrophy diseases. Then, we described the main approaches to derive human induced pluripotent stem cells-mesenchymal stem cells (hiPSC-MSCs). Finally, we underlined the low adipogenic capacity of hiPSC-MSCs compared to adult-MSCs and proposed several hypothesis to explain this feature.