Renal stem cell reprogramming: Prospects in regenerative medicine

doi:10.4252/wjsc.v6.i4.458

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Sep 26, 2014 (publication date) through Apr 26, 2024

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World Journal of Stem Cells

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1948-0210

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Stem Cells. Sep 26, 2014; 6(4): 458-466
Published online Sep 26, 2014. doi: 10.4252/wjsc.v6.i4.458

Renal stem cell reprogramming: Prospects in regenerative medicine

Elvin E Morales, Rebecca A Wingert

Elvin E Morales, Rebecca A Wingert, Department of Biological Sciences and Center for Zebrafish Research, University of Notre Dame, Notre Dame, IN 46556, United States

Author contributions: Morales EE and Wingert RA both designed the content of the manuscript, drafted and revised the manuscript, and approved the final version for publication.

Supported by National Institutes of Health, No. DP2 OD008470, R01 DK100237; Start-up funds from the University of Notre Dame and College of Science; and a generous donation for stem cell research to the University of Notre Dame by Elizabeth and Michael Gallagher on behalf of the Gallagher family

Correspondence to: Rebecca A Wingert, PhD, Department of Biological Sciences and Center for Zebrafish Research, University of Notre Dame, 100 Galvin Life Sciences, Notre Dame, IN 46556, United States. rwingert@nd.edu

Telephone: +1-574-6310907 Fax: +1-574-6317413

Received: July 26, 2014
Revised: August 21, 2014
Accepted: August 30, 2014
Published online: September 26, 2014

Core Tip

Core tip: The identification of regenerative therapies to treat kidney disease is an exciting but challenging area of ongoing scientific investigation. Cellular reprogramming may provide a tractable means to replace damaged renal tissue, and current researchers have pursued a number of innovative ways to produce renal cell types. Here we explore the issues confronting several reprogramming technologies, recent advances in reprogramming renal cells, and discuss areas of future scrutiny that are needed to help develop cell-based therapies for various kidney disease conditions.