Endothelial progenitor cells in cardiovascular diseases

doi:10.4252/wjsc.v6.i3.355

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World Journal of Stem Cells

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1948-0210

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Stem Cells. Jul 26, 2014; 6(3): 355-366
Published online Jul 26, 2014. doi: 10.4252/wjsc.v6.i3.355

Endothelial progenitor cells in cardiovascular diseases

Poay Sian Sabrina Lee, Kian Keong Poh

Poay Sian Sabrina Lee, Kian Keong Poh, Cardiac Department, National University Heart Centre, National University Health System, Singapore and Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119228, Singapore

Author contributions: Lee PSS and Poh KK contributed to this paper.

Supported by The National Medical Research Council, Singapore, No. NMRC/NIG/1038/2010; and the National University Health System Clinician Scientist Program (NCSP) from the Clinician Scientist Unit, Yong Loo Lin School of Medicine, National University of Singapore

Correspondence to: Kian Keong Poh, MBBChir, FRCP, Professor, Cardiac Department, National University Heart Centre, National University Health System, Singapore and Yong Loo Lin School of Medicine, National University of Singapore, 1E Kent Ridge Road, NUHS Tower Block, Level 9, Singapore 119228, Singapore. kian_keong_poh@nuhs.edu.sg

Telephone: +65-92373289 Fax: +65-68722998

Received: November 6, 2013
Revised: March 26, 2014
Accepted: April 3, 2014
Published online: July 26, 2014

Core Tip

Core tip: Our review summarizes the important associations between endothelial progenitor cells, cardiovascular risks, drugs and diseases. Current pharmacotherapies may enhance endothelial progenitor cell numbers and function. These and the evolving endothelial progenitor cell-based therapies may be important in the future treatment of cardiovascular diseases.