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World J Stem Cells. Jul 26, 2014; 6(3): 278-287
Published online Jul 26, 2014. doi: 10.4252/wjsc.v6.i3.278
Published online Jul 26, 2014. doi: 10.4252/wjsc.v6.i3.278
Mesenchymal stem cells for treatment of aortic aneurysms
Aika Yamawaki-Ogata, Xian-Ming Fu, Akihiko Usui, Yuji Narita, Department of Cardiac Surgery, Nagoya University Graduate School of Medicine, Nagoya 466-8550, Japan
Ryotaro Hashizume, Department of Pathology and Matrix Biology, Mie University Graduate School of Medicine, Tsu-Mie 514-8507, Japan
Xian-Ming Fu, Department of Cardiothoracic Surgery, The Second Xiangya Hospital, Central South University, Changsha 410011, Hunan Province, China
Author contributions: Yamawaki-Ogata A, Hashizume R and Fu XM performed the research; Yamawaki-Ogata A and Narita Y wrote the paper; Usui A and Narita Y reviewed the final manuscript.
Correspondence to: Yuji Narita, MD, PhD, Department of Cardiac Surgery, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-Ku, Nagoya 466-8550, Japan. ynarita@med.nagoya-u.ac.jp
Telephone: +81-52-7442376 Fax: +81-52-7442383
Received: November 15, 2013
Revised: January 21, 2014
Accepted: May 8, 2014
Published online: July 26, 2014
Processing time: 246 Days and 3.5 Hours
Revised: January 21, 2014
Accepted: May 8, 2014
Published online: July 26, 2014
Processing time: 246 Days and 3.5 Hours
Core Tip
Core tip: Aortic aneurysm (AA) is caused by an imbalance between synthesis and degradation of extracellular matrices (ECMs) such as collagen and elastin in the aortic wall. The chronic inflammation enhances the degradation of ECMs directly and indirectly. We hypothesized that administration of mesenchymal stem cells (MSCs) might be able to treat AA given the anti-inflammatory and immune-suppressive potential of MSC. In this article, we review papers that attempt to treat AA using MSCs with our recent results, as well as review the molecular pathogenesis of AA and characteristics of MSC.