Periosteum derived stem cells for regenerative medicine proposals: Boosting current knowledge

doi:10.4252/wjsc.v6.i3.266

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World Journal of Stem Cells

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1948-0210

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Stem Cells. Jul 26, 2014; 6(3): 266-277
Published online Jul 26, 2014. doi: 10.4252/wjsc.v6.i3.266

Periosteum derived stem cells for regenerative medicine proposals: Boosting current knowledge

Concetta Ferretti, Monica Mattioli-Belmonte

Concetta Ferretti, Monica Mattioli-Belmonte, Department of Clinical and Molecular Sciences, School of Medicine, Università Politecnica delle Marche, 60126 Ancona, Italy

Author contributions: Ferretti C and Mattioli-Belmonte M equally contributed to conception and acquisition of data as well as to article drafting and revising.

Supported by Italian FIRB and PRIN project grants, No. 2010J8RYS7 and No. RBAP10MLK7

Correspondence to: Dr. Monica Mattioli-Belmonte, Department of Clinical and Molecular Sciences, School of Medicine, Università Politecnica delle Marche, Via Tronto 10/A, 60126 Ancona, Italy. m.mattioli@univpm.it

Telephone: +39-71-2206077 Fax: +39-71-2206073

Received: October 25, 2013
Revised: January 9, 2014
Accepted: April 25, 2014
Published online: July 26, 2014

Core Tip

Core tip: Periosteum provides a niche for pluripotent cells. Elucidating periosteum regenerative potential is a hot topic in orthopaedics. This review discusses the state of the art of osteochondral tissue engineering rested on periosteum derived cells and suggests upcoming research directions aimed to the development of new standards of care for the maintenance of bone mass both in post-trauma healing process and in physiological turn-over.