Published online Apr 26, 2014. doi: 10.4252/wjsc.v6.i2.163
Revised: December 20, 2013
Accepted: March 3, 2014
Published online: April 26, 2014
Core tip: Type 1 diabetes is caused by a cell-mediated autoimmune destruction of pancreatic β cells. The transplantation of pancreatic islets provides a cure for this disorder. In this review, we first summarize the current knowledge on the pathogenesis of type 1 diabetes and on the therapeutic options for this disorder. Next we discuss the impact of mesenchymal stem cells on vascularization and immunomodulation of islet transplantation.