Review
Copyright ©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Stem Cells. Jun 26, 2025; 17(6): 107833
Published online Jun 26, 2025. doi: 10.4252/wjsc.v17.i6.107833
Mesenchymal stem cell-based therapy for peripheral nerve injuries: A promise or reality?
Lucas Vinícius de Oliveira Ferreira, Kelly Cristine Santos Roballo, Rogério Martins Amorim
Lucas Vinícius de Oliveira Ferreira, Rogério Martins Amorim, Department of Veterinary Clinic, School of Veterinary Medicine and Animal Science, São Paulo State University, Botucatu 18618-681, São Paulo, Brazil
Lucas Vinícius de Oliveira Ferreira, Rogério Martins Amorim, Center for Translational Research in Regenerative Medicine, Institute of Biotechnology, São Paulo State University, Botucatu 18607-440, São Paulo, Brazil
Kelly Cristine Santos Roballo, Department of Biomedical Sciences and Pathobiology, Virginia Maryland College of Veterinary Medicine, Virginia Tech, Blacksburg, VA 24061, United States
Kelly Cristine Santos Roballo, Biomedical Affairs and Research, Edward Via College of Osteopathic Medicine, Blacksburg, VA 24060, United States
Author contributions: Ferreira LVO, Roballo KCS, and Amorim RM made equal contributions to this study; Ferreira LVO, Roballo KCS, and Amorim RM prepared and wrote the manuscript; All authors read and approved the final manuscript.
Supported by the Doctoral Scholarship granted by the São Paulo Research Foundation (FAPESP), 2024/19980-0.
Conflict-of-interest statement: All authors report no relevant conflicts of interest for this article.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Lucas Vinícius de Oliveira Ferreira, Department of Veterinary Clinic, School of Veterinary Medicine and Animal Science, São Paulo State University, Prof. Dr. Walter Maurício Corrêa Street, s/n, Botucatu 18618-681, São Paulo, Brazil. lv.ferreira@unesp.br
Received: March 31, 2025
Revised: April 23, 2025
Accepted: June 9, 2025
Published online: June 26, 2025
Processing time: 88 Days and 15.2 Hours
Core Tip

Core Tip: Mesenchymal stem cells (MSCs) offer a promising therapeutic approach for peripheral nerve injuries involving nerve gap by promoting axonal regeneration, modulating inflammation, secreting neurotrophic factors, and exhibiting transdifferentiation capacity. These properties position MSCs as a compelling alternative to conventional treatments. However, challenges still exist for the clinical use of MSCs, requiring further research to fully unlock their therapeutic potential and translate these advancements into effective nerve regeneration strategies.