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©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Stem Cells. Jul 26, 2023; 15(7): 687-700
Published online Jul 26, 2023. doi: 10.4252/wjsc.v15.i7.687
Published online Jul 26, 2023. doi: 10.4252/wjsc.v15.i7.687
Neural stem cells for Parkinson’s disease management: Challenges, nanobased support, and prospects
Tuba Oz, Małgorzata Kujawska, Department of Toxicology, Poznan University of Medical Sciences, Poznan 60-631, Poland
Ajeet Kaushik, NanoBioTech Laboratory, Health System Engineering, Department of Environmental Engineering, Florida Polytechnic University, Lakeland, FL 33805, United States
Ajeet Kaushik, School of Engineering, University of Petroleum and Energy Studies, Dehradun 248007, India
Author contributions: Oz T and Kujawska M designed the review; All authors contributed to the writing of the paper and artwork and gave approval of the final version.
Supported by Narodowe Centrum Nauki , No. 2021/42/E/NZ7/00246 .
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Małgorzata Kujawska, MSc, PhD, DSc, Professor, Department of Toxicology, Poznan University of Medical Sciences, Dojazd 30, Poznan 60-631, Poland. kujawska@ump.edu.pl
Received: February 28, 2023
Peer-review started: February 28, 2023
First decision: April 19, 2023
Revised: April 27, 2023
Accepted: May 16, 2023
Article in press: May 16, 2023
Published online: July 26, 2023
Peer-review started: February 28, 2023
First decision: April 19, 2023
Revised: April 27, 2023
Accepted: May 16, 2023
Article in press: May 16, 2023
Published online: July 26, 2023
Core Tip
Core tip: Neural stem cell (NSC) transplantation is a groundbreaking therapy with therapeutic effects for many neurodegenerative diseases. Parkinson’s disease (PD) is the second most common neurodegenerative movement disorder. The ability of NSCs for neural differentiation has been suggested as an effective mechanism in PD subjected to cell transplantation. Here, the potential therapeutic mechanisms, challenges, nanobased support, and manifestations of NSCs in PD are discussed, along with examples of preclinical and clinical studies.