World J Stem Cells. May 26, 2023; 15(5): 302-322 Published online May 26, 2023. doi: 10.4252/wjsc.v15.i5.302
Delineating the glioblastoma stemness by genes involved in cytoskeletal rearrangements and metabolic alterations
Żaneta Kałuzińska-Kołat, Damian Kołat, Katarzyna Kośla, Elżbieta Płuciennik, Andrzej K Bednarek
Żaneta Kałuzińska-Kołat, Damian Kołat, Department of Experimental Surgery, Medical University of Lodz, Lodz 90-136, Lodzkie, Poland
Żaneta Kałuzińska-Kołat, Damian Kołat, Katarzyna Kośla, Andrzej K Bednarek, Department of Molecular Carcinogenesis, Medical University of Lodz, Lodz 90-752, Lodzkie, Poland
Elżbieta Płuciennik, Department of Functional Genomics, Medical University of Lodz, Lodz 90-752, Lodzkie, Poland
Author contributions: Kałuzińska-Kołat Ż conceptualized the article; Bednarek AK supervised the article; Kałuzińska-Kołat Ż, Kołat D, Kośla K, Płuciennik E, and Bednarek AK reviewed the literature; Kałuzińska-Kołat Ż and Kołat D visualized the figures and prepared the tables; Kałuzińska-Kołat Ż wrote the original draft; Kałuzińska-Kołat Ż, Kołat D, Kośla K, Płuciennik E, and Bednarek AK reviewed and edited article; all authors have read and agreed to the published version of the manuscript.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Corresponding author: Żaneta Kałuzińska-Kołat, BSc, MSc, Research Assistant, Teaching Assistant, Department of Experimental Surgery, Medical University of Lodz, 60 Narutowicza, Lodz 90-136, Lodzkie, Poland. zaneta.kaluzinska@umed.lodz.pl
Received: December 10, 2022 Peer-review started: December 10, 2022 First decision: January 23, 2023 Revised: February 3, 2023 Accepted: March 8, 2023 Article in press: March 8, 2023 Published online: May 26, 2023 Processing time: 166 Days and 22.8 Hours
Core Tip
Core Tip: Glioblastoma stemness intensifies the resistance to treatment via increased invasiveness. Among the processes crucial for glioblastoma stem cells, metabolism is known to influence invasion. However, the cytoskeleton is currently negligent in glioblastoma stemness research, while it also regulates invasion. Herein, we review the link between stemness and cytoskeleton/metabolism-related genes that we previously identified in glioblastoma. These genes influence stemness via numerous biological processes; for some genes, clinical trials are currently ongoing. Others were connected to glioblastoma stemness for the first time. Future glioblastoma-related research should delve into the cytoskeleton since the concept is already encouraging.
