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©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Stem Cells. Feb 26, 2023; 15(2): 16-30
Published online Feb 26, 2023. doi: 10.4252/wjsc.v15.i2.16
Published online Feb 26, 2023. doi: 10.4252/wjsc.v15.i2.16
Mesenchymal stem cells in ischemic tissue regeneration
Renata Szydlak, Chair of Medical Biochemistry, Faculty of Medicine, Jagiellonian University Medical College, Kraków 31-034, Poland
Author contributions: Szydlak R wrote the paper.
Conflict-of-interest statement: The author reports having no relevant conflicts of interest for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Renata Szydlak, PhD, Postdoc, Research Assistant Professor, Chair of Medical Biochemistry, Faculty of Medicine, Jagiellonian University Medical College, Kopernika 7, Kraków 31-034, Poland. renata.szydlak@doctoral.uj.edu.pl
Received: October 14, 2022
Peer-review started: October 14, 2022
First decision: November 5, 2022
Revised: November 10, 2022
Accepted: January 18, 2023
Article in press: January 18, 2023
Published online: February 26, 2023
Peer-review started: October 14, 2022
First decision: November 5, 2022
Revised: November 10, 2022
Accepted: January 18, 2023
Article in press: January 18, 2023
Published online: February 26, 2023
Core Tip
Core Tip: Mesenchymal stem cell (MSC) transplantation is an innovative therapy with positive therapeutic effects for many ischemic diseases. Ischemia of an area is defined as insufficient blood supply to specific tissues and various organs or individual parts of the body. The leading cause of tissue ischemia is the narrowing or blockage of the lumen of an artery, most often due to the formation of atherosclerotic plaques, thrombus, or spasms of a specific artery. Here, the potential therapeutic mechanisms of MSCs in ischemic diseases were discussed, along with examples of preclinical and clinical studies.