Review
Copyright ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Stem Cells. Jul 26, 2022; 14(7): 435-452
Published online Jul 26, 2022. doi: 10.4252/wjsc.v14.i7.435
Therapeutic potential of dental pulp stem cells and their derivatives: Insights from basic research toward clinical applications
Sheng-Meng Yuan, Xue-Ting Yang, Si-Yuan Zhang, Wei-Dong Tian, Bo Yang
Sheng-Meng Yuan, Xue-Ting Yang, Si-Yuan Zhang, Wei-Dong Tian, Bo Yang, State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Engineering Research Center of Oral Translational Medicine, National Engineering Laboratory for Oral Regenerative Medicine, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, Sichuan Province, China
Sheng-Meng Yuan, Xue-Ting Yang, Wei-Dong Tian, Bo Yang, Department of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, Sichuan Province, China
Author contributions: Yuan SM wrote the paper and drew the figure; Yang XT revised the original manuscript; Zhang SY reviewed the manuscript and revised the language; Tian WD and Yang B proposed the ideas and approved the manuscript to be published.
Supported by National Natural Science Foundation of China, No. U21A20369; Sichuan Science and Technology Program, No. 2021YJ0147; and Research and Develop Program, West China Hospital of Stomatology Sichuan University, No. RD-02-202113.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Bo Yang, DDS, PhD, Academic Fellow, Chief Doctor, State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Engineering Research Center of Oral Translational Medicine, National Engineering Laboratory for Oral Regenerative Medicine, West China Hospital of Stomatology, Sichuan University, No. 14 3rd Section, Renmin South Road, Chengdu 610041, Sichuan Province, China. dr.yangbo@scu.edu.cn
Received: March 14, 2022
Peer-review started: March 14, 2022
First decision: May 11, 2022
Revised: May 25, 2022
Accepted: June 20, 2022
Article in press: June 20, 2022
Published online: July 26, 2022
Core Tip

Core Tip: In this review, we aim to outline the present understanding of the potential application of dental pulp stem cells (DPSCs) and their derivatives in the field of regenerative medicine. DPSCs have different properties and regenerative potentials according to the age and health condition of the donor. For therapeutic applications, DPSCs can be administered through different methodologies, including by single injections and the transplantation of the cells and their derivatives with a support, as cell sheets or as cell spheroids. The underlying mechanisms of the regenerative potential of DPSCs and their derivatives may occur through direct regulation and immunomodulatory and paracrine effects.