Review
Copyright ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Stem Cells. Sep 26, 2021; 13(9): 1160-1176
Published online Sep 26, 2021. doi: 10.4252/wjsc.v13.i9.1160
Effects of living and metabolically inactive mesenchymal stromal cells and their derivatives on monocytes and macrophages
Alexia Nedel Sant'Ana, Anelise Bergmann Araújo, Fabiany da Costa Gonçalves, Ana Helena Paz
Alexia Nedel Sant'Ana, Ana Helena Paz, Laboratório de Células Tecidos e Genes, Hospital de Clínicas de Porto Alegre, Porto Alegre 90035-903, RS, Brazil
Anelise Bergmann Araújo, Centro de Processamento Celular, Hospital de Clínicas de Porto Alegre, Porto Alegre 90035-903, RS, Brazil
Fabiany da Costa Gonçalves, Department of Internal Medicine, Erasmus Medical Center, Rotterdam 3015 GD, Netherlands
Ana Helena Paz, Departamento de Ciências Morfológicas, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Porto Alegre 90035-903, RS, Brazil
Author contributions: Sant’Ana AN, Araújo AB, Gonçalves FDC and Paz AH performed data collection, wrote and revised the paper.
Supported by Fundo de Incentivo à Pesquisa e Eventos (Fipe) - Hospital de Clínicas de Porto Alegre, No. GPPG 2017-0004.
Conflict-of-interest statement: Authors declare no conflict of interests for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Anelise Bergmann Araújo, DSc, Research Scientist, Technician, Centro de Processamento Celular, Hospital de Clínicas de Porto Alegre, Rua Ramiro Barcelos 2350, Porto Alegre 90035-903, RS, Brazil. anelise_araujo@yahoo.com.br
Received: February 23, 2021
Peer-review started: February 23, 2021
First decision: April 20, 2021
Revised: May 1, 2021
Accepted: September 3, 2021
Article in press: September 3, 2021
Published online: September 26, 2021
Core Tip

Core Tip: Mesenchymal stromal cells (MSCs) and their derivatives possess immunoregulatory and regenerative properties that involve the classical activation of monocytes and macrophages towards an anti-inflammatory profile, marked by the secretion of anti-inflammatory and reparative factors that guide the inflammation resolution and healing processes. This review will comprise the effects of living and metabolically inactive MSCs, MSC extracellular vesicles, subcellular microparticles, and cell extracts on monocytes and macrophages, as well as several possibilities of therapeutic applications.