Zhang W, Ke CH, Guo HH, Xiao L. Antler stem cells and their potential in wound healing and bone regeneration. World J Stem Cells 2021; 13(8): 1049-1057 [PMID: 34567424 DOI: 10.4252/wjsc.v13.i8.1049]
Corresponding Author of This Article
Li Xiao, MS, Assistant Professor, Guangdong Laboratory Animals Monitoring Institute and Guangdong Provincial Key Laboratory of Laboratory Animals, No. 11 Fengxin Road, Science City, Guangzhou 510080, Guangdong Province, China. xiaoli19900202@163.com
Research Domain of This Article
Biology
Article-Type of This Article
Minireviews
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Stem Cells. Aug 26, 2021; 13(8): 1049-1057 Published online Aug 26, 2021. doi: 10.4252/wjsc.v13.i8.1049
Antler stem cells and their potential in wound healing and bone regeneration
Wei Zhang, Chang-Hong Ke, Hai-Hua Guo, Li Xiao
Wei Zhang, Medical Imaging Center, The First Affiliated Hospital of Jinan University, Jinan University, Guangzhou 510080, Guangdong Province, China
Wei Zhang, Chang-Hong Ke, Research & Development Center, YZ Health-tech Inc., Zhuhai 519000, Guangdong Province, China
Chang-Hong Ke, School of Pharmacy, Jinan University, Guangzhou 510080, Guangdong Province, China
Hai-Hua Guo, Institute of Biomedical and Pharmaceutical Sciences, Guangdong University of Technology, Guangzhou 510006, Guangdong Province, China
Li Xiao, Guangdong Laboratory Animals Monitoring Institute and Guangdong Provincial Key Laboratory of Laboratory Animals, Guangzhou 510080, Guangdong Province, China
Author contributions: Zhang W and Ke CH contributed equally to this work; Zhang W, Ke CH, and Xiao L designed this paper; Zhang W and Ke KH wrote the paper; Guo HH and Xiao L made the pictures and revised the paper; all authors have read and approved the final manuscript.
Conflict-of-interest statement: The authors declare that they have no conflict of interest to disclose.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Li Xiao, MS, Assistant Professor, Guangdong Laboratory Animals Monitoring Institute and Guangdong Provincial Key Laboratory of Laboratory Animals, No. 11 Fengxin Road, Science City, Guangzhou 510080, Guangdong Province, China. xiaoli19900202@163.com
Received: February 27, 2021 Peer-review started: February 27, 2021 First decision: April 20, 2021 Revised: May 10, 2021 Accepted: July 27, 2021 Article in press: July 27, 2021 Published online: August 26, 2021
Core Tip
Core Tip: With the development of regenerative medicine in recent years, stem cell-based strategies for wound healing and bone repair have received increasing attention. Deer are the only mammals that can fully regenerate a complex organ (antler) annually. In this paper, by reviewing current publications, we summarize the molecular characterizations, locations, and functions of antler stem cells (AnSCs) to deepen our understanding of the unique stem cell-based epimorphic process in mammals. We also describe the research progress and future directions of AnSCs-based/cell-free therapies for wound healing and bone repair, focusing on the use of antlerogenic periosteum cells, pedicle periosteum cells, reserve mesenchyme cells, and extracellular molecules derived from AnSCs.
