Copyright
©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Stem Cells. Jul 26, 2021; 13(7): 914-933
Published online Jul 26, 2021. doi: 10.4252/wjsc.v13.i7.914
Published online Jul 26, 2021. doi: 10.4252/wjsc.v13.i7.914
Current advances of stem cell-based therapy for kidney diseases
Chee-Yin Wong, Faculty of Medicine and Health Sciences, Universiti Tunku Abdul Rahman, Kajang 43000, Selangor, Malaysia
Chee-Yin Wong, Research Department, Cytopeutics, Cyberjaya 63000, Selangor, Malaysia
Author contributions: Wong CY compiled the data and wrote the manuscript.
Conflict-of-interest statement: Author declares no conflict of interests for this article
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Chee-Yin Wong, PhD, Honorary Research Fellow, Faculty of Medicine and Health Sciences, Universiti Tunku Abdul Rahman, Jalan Sungai Long, Bandar Sungai Long, Kajang 43000, Selangor, Malaysia. wongcyin@gmail.com
Received: March 13, 2021
Peer-review started: March 13, 2021
First decision: April 6, 2021
Revised: April 10, 2021
Accepted: July 12, 2021
Article in press: July 12, 2021
Published online: July 26, 2021
Peer-review started: March 13, 2021
First decision: April 6, 2021
Revised: April 10, 2021
Accepted: July 12, 2021
Article in press: July 12, 2021
Published online: July 26, 2021
Core Tip
Core Tip: Stem cells have the potential to be the next regenerative medicine to treat kidney diseases. There is mounting evidence suggesting that stem cell-based therapy has renoprotective effects to attenuate kidney damage while improving kidney function. This review summarises the current stem cell-based therapy approaches to treat kidney diseases in experimental models and the outcomes from human clinical trials reported to date.